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Table 1 Characteristics of the asthma patients included in the study

From: Bronchial thermoplasty in asthma: an exploratory histopathological evaluation in distinct asthma endotypes/phenotypes

Parameters

All patients (N = 30)

Asthma endotypes/phenotypes

Eos ≥ 300/μl (N = 7)

Eos < 300/μl (N = 23)

P value*

Atopy (N = 19)

No Atopy (N = 11)

P value*

Allergy (N = 16)

No allergy (N = 14)

P value*

Smoke exposure (N = 10)

No smoke exposure (N = 20)

P value*

Age, years, mean ± SEM

57.8 ± 2.9

50.1 ± 6.1

60.1 ± 3.1

0.128b

57.4 ± 3.9

58.4 ± 4.0

0.832b

53.5 ± 4.3

62.6 ± 3.3

0.176b

63.0 ± 1.9

55.2 ± 4.1

0.108b

Gender, Female/Male

19/11

5/2

14/9

1.000a

11/8

8/3

0.466a

12/4

7/7

0.257a

5/5

14/6

0.425a

BMI, mean ± SEM

27.8 ± 0.9

29.7 ± 2.7

27.2 ± 0.9

0.202b

27.4 ± 1.2

28.5 ± 1.4

0.714b

28.3 ± 1.4

27.2 ± 1.1

0.533b

28.4 ± 1.1

27.5 ± 1.3

0.644b

Pack Years, mean ± SEM

14.0 ± 4.2

8.3 ± 4.4

15.6 ± 5.1

0.653b

12.5 ± 5.5

16.8 ± 5.9

0.342b

16.3 ± 6.5

11.4 ± 4.7

0.622b

31.5 ± 8.5

4.3 ± 2.6

 < 0.001b

Oral corticosteroids, n (%)

21 (70.0)

4 (57.1)

17 (73.9)

0.640a

13 (68.4)

8 (72.7)

1.000a

11 (68.8)

10 (71.4)

1.000a

7 (70.0)

14 (70.0)

1.000a

Oral corticosteroids, mg, mean ± SEM

13.8 ± 1.5

16.3 ± 5.5

13.2 ± 1.5

0.171b

14.4 ± 1.8

12.8 ± 2.9

0.453b

12.3 ± 2.4

15.5 ± 1.9

0.201b

12.5 ± 2.7

14.4 ± 1.9

0.511b

FEV1% of predicted value, mean ± SEM

66.9 ± 3.6

74.5 ± 6.1

64.6 ± 4.3

0.111b

68.0 ± 5.0

65.1 ± 4.9

0.863b

64.3 ± 4.6

69.9 ± 5.6

0.662b

62.8 ± 8.0

69.0 ± 3.7

0.281b

FVC % of predicted value, mean ± SEM

94.7 ± 3.5

93.3 ± 8.1

95.1 ± 3.9

0.713b

95.5 ± 4.5

93.3 ± 5.8

0.983b

92.4 ± 5.3

97.4 ± 4.4

0.506b

101.5 ± 4.9

91.3 ± 4.5

0.248b

FEV1/FVC, mean ± SEM

73.0 ± 3.2

84.2 ± 5.7

69.6 ± 3.6

0.042b

73.7 ± 4.5

71.8 ± 4.5

0.880b

72.5 ± 4.3

73.6 ± 5.0

0.835b

62.8 ± 6.0

78.1 ± 3.4

0.022b

RV % of predicted value, mean ± SEM

118.5 ± 6.8

103.8 ± 16.2

123.0 ± 7.4

0.249b

118.7 ± 9.8

118.2 ± 8.4

0.813b

123.7 ± 10.5

112.5 ± 8.5

0.480b

139.7 ± 11.2

107.9 ± 7.7

0.028b

TLC % of predicted value, mean ± SEM

104.3 ± 3.1

98.3 ± 8.5

106.1 ± 3.2

0.364b

105.0 ± 4.5

103.1 ± 3.8

0.651b

105.4 ± 4.6

103.0 ± 4.2

0.835b

116.3 ± 3.5

98.3 ± 3.7

0.007b

RV/TLC, mean ± SEM

108.6 ± 4.2

99.5 ± 8.9

111.4 ± 4.7

0.315b

106.1 ± 5.0

113.1 ± 7.5

0.621b

112.1 ± 6.5

104.7 ± 5.1

0.383b

112.6 ± 6.5

106.6 ± 5.4

0.481b

DLCO % of predicted value, mean ± SEM

89.1 ± 3.8

89.1 ± 7.6

89.2 ± 4.5

0.787b

88.8 ± 4.5

89.7 ± 7.2

0.813b

88.1 ± 5.5

90.4 ± 5.4

0.835b

87.8 ± 6.6

89.8 ± 4.8

0.538b

Reversibility FEV1%, mean ± SEM

12.0 ± 1.9

6.8 ± 2.0

13.6 ± 2.3

0.126b

11.5 ± 2.1

12.6 ± 3.5

0.859b

13.6 ± 2.5

10.4 ± 2.8

0.275b

10.2 ± 2.0

12.8 ± 2.6

0.601b

FeNO ppm, mean ± SEM

37.9 ± 5.9

53.1 ± 15.6

33.3 ± 5.9

0.169b

38.8 ± 7.2

36.4 ± 10.4

0.366b

36.4 ± 7.5

39.6 ± 9.5

0.803b

34.4 ± 8.2

39.7 ± 7.9

0.775b

IgE U/ml, mean ± SEM

349.5 ± 96.9

492.1 ± 129.5

306.1 ± 120.1

0.053b

524.4 ± 138.6

47.4 ± 7.5

 < 0.001b

508.9 ± 170.1

167.4 ± 43.8

0.244b

388.7 ± 249.6

329.9 ± 81.8

0.692b

  1. *Comparisons were made by Fisher’s exact test (a) or by the Mann–Whitney test (b)
  2. SEM standard error of the mean, BMI body mass index, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, TLC total lung capacity, RV residual volume, DLCO diffusing capacity for carbon monoxide, FeNO fractional exhaled NO, IgE immunoglobulin E, Eos eosinophils