Parameters | All patients (N = 30) | Asthma endotypes/phenotypes | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Eos ≥ 300/μl (N = 7) | Eos < 300/μl (N = 23) | P value* | Atopy (N = 19) | No Atopy (N = 11) | P value* | Allergy (N = 16) | No allergy (N = 14) | P value* | Smoke exposure (N = 10) | No smoke exposure (N = 20) | P value* | ||
Age, years, mean ± SEM | 57.8 ± 2.9 | 50.1 ± 6.1 | 60.1 ± 3.1 | 0.128b | 57.4 ± 3.9 | 58.4 ± 4.0 | 0.832b | 53.5 ± 4.3 | 62.6 ± 3.3 | 0.176b | 63.0 ± 1.9 | 55.2 ± 4.1 | 0.108b |
Gender, Female/Male | 19/11 | 5/2 | 14/9 | 1.000a | 11/8 | 8/3 | 0.466a | 12/4 | 7/7 | 0.257a | 5/5 | 14/6 | 0.425a |
BMI, mean ± SEM | 27.8 ± 0.9 | 29.7 ± 2.7 | 27.2 ± 0.9 | 0.202b | 27.4 ± 1.2 | 28.5 ± 1.4 | 0.714b | 28.3 ± 1.4 | 27.2 ± 1.1 | 0.533b | 28.4 ± 1.1 | 27.5 ± 1.3 | 0.644b |
Pack Years, mean ± SEM | 14.0 ± 4.2 | 8.3 ± 4.4 | 15.6 ± 5.1 | 0.653b | 12.5 ± 5.5 | 16.8 ± 5.9 | 0.342b | 16.3 ± 6.5 | 11.4 ± 4.7 | 0.622b | 31.5 ± 8.5 | 4.3 ± 2.6 |  < 0.001b |
Oral corticosteroids, n (%) | 21 (70.0) | 4 (57.1) | 17 (73.9) | 0.640a | 13 (68.4) | 8 (72.7) | 1.000a | 11 (68.8) | 10 (71.4) | 1.000a | 7 (70.0) | 14 (70.0) | 1.000a |
Oral corticosteroids, mg, mean ± SEM | 13.8 ± 1.5 | 16.3 ± 5.5 | 13.2 ± 1.5 | 0.171b | 14.4 ± 1.8 | 12.8 ± 2.9 | 0.453b | 12.3 ± 2.4 | 15.5 ± 1.9 | 0.201b | 12.5 ± 2.7 | 14.4 ± 1.9 | 0.511b |
FEV1% of predicted value, mean ± SEM | 66.9 ± 3.6 | 74.5 ± 6.1 | 64.6 ± 4.3 | 0.111b | 68.0 ± 5.0 | 65.1 ± 4.9 | 0.863b | 64.3 ± 4.6 | 69.9 ± 5.6 | 0.662b | 62.8 ± 8.0 | 69.0 ± 3.7 | 0.281b |
FVC % of predicted value, mean ± SEM | 94.7 ± 3.5 | 93.3 ± 8.1 | 95.1 ± 3.9 | 0.713b | 95.5 ± 4.5 | 93.3 ± 5.8 | 0.983b | 92.4 ± 5.3 | 97.4 ± 4.4 | 0.506b | 101.5 ± 4.9 | 91.3 ± 4.5 | 0.248b |
FEV1/FVC, mean ± SEM | 73.0 ± 3.2 | 84.2 ± 5.7 | 69.6 ± 3.6 | 0.042b | 73.7 ± 4.5 | 71.8 ± 4.5 | 0.880b | 72.5 ± 4.3 | 73.6 ± 5.0 | 0.835b | 62.8 ± 6.0 | 78.1 ± 3.4 | 0.022b |
RV % of predicted value, mean ± SEM | 118.5 ± 6.8 | 103.8 ± 16.2 | 123.0 ± 7.4 | 0.249b | 118.7 ± 9.8 | 118.2 ± 8.4 | 0.813b | 123.7 ± 10.5 | 112.5 ± 8.5 | 0.480b | 139.7 ± 11.2 | 107.9 ± 7.7 | 0.028b |
TLC % of predicted value, mean ± SEM | 104.3 ± 3.1 | 98.3 ± 8.5 | 106.1 ± 3.2 | 0.364b | 105.0 ± 4.5 | 103.1 ± 3.8 | 0.651b | 105.4 ± 4.6 | 103.0 ± 4.2 | 0.835b | 116.3 ± 3.5 | 98.3 ± 3.7 | 0.007b |
RV/TLC, mean ± SEM | 108.6 ± 4.2 | 99.5 ± 8.9 | 111.4 ± 4.7 | 0.315b | 106.1 ± 5.0 | 113.1 ± 7.5 | 0.621b | 112.1 ± 6.5 | 104.7 ± 5.1 | 0.383b | 112.6 ± 6.5 | 106.6 ± 5.4 | 0.481b |
DLCO % of predicted value, mean ± SEM | 89.1 ± 3.8 | 89.1 ± 7.6 | 89.2 ± 4.5 | 0.787b | 88.8 ± 4.5 | 89.7 ± 7.2 | 0.813b | 88.1 ± 5.5 | 90.4 ± 5.4 | 0.835b | 87.8 ± 6.6 | 89.8 ± 4.8 | 0.538b |
Reversibility FEV1%, mean ± SEM | 12.0 ± 1.9 | 6.8 ± 2.0 | 13.6 ± 2.3 | 0.126b | 11.5 ± 2.1 | 12.6 ± 3.5 | 0.859b | 13.6 ± 2.5 | 10.4 ± 2.8 | 0.275b | 10.2 ± 2.0 | 12.8 ± 2.6 | 0.601b |
FeNO ppm, mean ± SEM | 37.9 ± 5.9 | 53.1 ± 15.6 | 33.3 ± 5.9 | 0.169b | 38.8 ± 7.2 | 36.4 ± 10.4 | 0.366b | 36.4 ± 7.5 | 39.6 ± 9.5 | 0.803b | 34.4 ± 8.2 | 39.7 ± 7.9 | 0.775b |
IgE U/ml, mean ± SEM | 349.5 ± 96.9 | 492.1 ± 129.5 | 306.1 ± 120.1 | 0.053b | 524.4 ± 138.6 | 47.4 ± 7.5 |  < 0.001b | 508.9 ± 170.1 | 167.4 ± 43.8 | 0.244b | 388.7 ± 249.6 | 329.9 ± 81.8 | 0.692b |