Fig. 4

Expression of glucocorticoid receptor (GR) in endobronchial biopsies obtained from severe asthma patients using a specific monoclonal antibody. A Representative microphotographs. Lower panels show enlargement of the areas in red boxes. B Representative microphotographs showing increased localization of GR in the nuclei after BT. C expression score in epithelial cells, subepithelial mesenchymal cells and in the nuclei of all cells from patients with severe asthma before and after thermoplasty. The p value was calculated using mixed multinomial (ordinal) logistic regression models, where the factor patient was included as a random effect. BT bronchial thermoplasty