| BGF 320/18/9.6 µg (N = 22) | GFF 18/9.6 µg (N = 23) |
---|---|---|
Primary FRI endpoints | ||
 Untrimmed siVaw at TLCa |  |  |
  Geometric LSM, mL/L | 2.04 | 1.87 |
  LSM ratio, BGF versus GFF (95% CI) | 1.09 (1.03, 1.16)** | |
 Untrimmed siRaw at TLCa |  |  |
  Geometric LSM, kPa·s | 0.18 | 0.19 |
  LSM ratio, BGF versus GFF (95% CI) | 0.97 (0.85, 1.10) | |
Secondary endpoints | ||
 FRI | ||
  Untrimmed iVaw at TLCa |  |  |
   Geometric LSM, mL | 2.62 | 2.38 |
   LSM ratio, BGF versus GFF (95% CI) | 1.10 (1.03, 1.17)** | |
  iRaw at TLCa |  |  |
   Geometric LSM, kPa s/L | 0.14 | 0.15 |
   LSM ratio, BGF versus GFF (95% CI) | 0.96 (0.85, 1.09) | |
 Spirometry | ||
  FEV1 b |  |  |
   LS mean change from baseline (SE), mL | 341 (69) | 282 (69) |
   LSM difference, BGF versus GFF (95% CI) | 60 (–14, 133) | |
 Body plethysmography | ||
  FRC, mL (95% CI)c |  |  |
   LS mean change from baseline (SE) | –310 (140) | –460 (142) |
   LSM difference, BGF versus GFF (95% CI) | 150 (–230, 530) | |
Other endpoints | Â | |
 FVCc |  | |
  LS mean change from baseline (SE), mL | 393 (94) | 299 (95) |
  LSM difference, BGF versus GFF (95% CI) | 94 (− 70, 259) | |
 FEF25–75c |  | |
  LS mean change from baseline (SE), mL/s | 221 (102) | 120 (103) |
  LSM difference, BGF versus GFF (95% CI) | 101 (− 47, 250) |