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Table 4 Univariate and multivariable analysis of association of miRNAs expression with asthma status, age group and age group*asthma status interaction

From: Circulating miRNA expression in asthmatics is age-related and associated with clinical asthma parameters, respiratory function and systemic inflammation

miRNA Variable Univariate analysis Multivariable analysis
Beta (95% CI) p-value Beta (95% CI) p-value Model statistics
miRNA-146a Asthma status 0.01 (− 0.18 to 0.2) 0.92 0.02 (− 0.16 to 0.19) 0.86 R2 = 0.13, R2 Corr. = 0.11, F(3,111) = 5.5, p = 0.002
Age group  − 0.28 (− 0.46 to − 0.11) 0.002  − 0.28 (−  0.46 to 0.11) 0.002
Age group*asthma status Chi2 = 6.27, p(LR) = 0.01 0.22 (0.05 to 0.4) 0.01
miRNA-126a Asthma status  − 0.09 (− 0.28 to 0.1) 0.35  − 0.12 (− 0.29 to 0.05) 0.17 R2 = 0.22, R2 Corr. = 0.2, F(3,105) = 9.9, p < 0.001
Age group  − 0.45 (− 0.62 to − 0.28)  < 0.001  − 0.46 (− 0.63 to - 0.29)  < 0.001
Age group*asthma status Chi2 = 0.001. p(LR) = 0.98 0 (− 0.17 to 0.17) 0.98
miRNA-106a Asthma status  − 0.12 (− 0.3 to 0.06) 0.2  − 0.13 (− 0.3 to 0.05) 0,15 R2 = 0.12, R2 Corr. = 0.09, F(3,111) = 5, p = 0.003
Age group  − 0.31 (− 0.49 to − 0.14)  < 0.001  − 0.32 (− 0.49 to  − 0.14)  < 0.001
Age group*asthma status Chi2 = 0.49. p(LR) = 0.49  − 0.06 (− 0.24 to 0.12) 0.49
miRNA-19b Asthma status 0.17 (− 0.01 to 0.35) 0.07 0.17 (− 0.01 to 0.35) 0.06 R2 = 0.13, R2 Corr. = 0.1, F(3,111) = 5.45, p = 0.002
Age group  − 0.29 (− 0.47 to − 0.12) 0.001  − 0.29 (− 0.46 to  − 0.11) 0.002
Age group*asthma status Chi2 = 2.05, p(LR) = 0.15 0.13 (− 0.05 to 0.3) 0.16
  1. In the model, each tested miRNA was used as the dependent variable, while the independent variables were asthma status (asthma vs controls), age group (elderly vs. non-elderly), and age group*asthma status interaction. miRNA expression [2−ΔCt] was log-2 transformed before the analysis. The bold text indicates a statistically significant p-value