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Table 4 Univariate and multivariable analysis of association of miRNAs expression with asthma status, age group and age group*asthma status interaction

From: Circulating miRNA expression in asthmatics is age-related and associated with clinical asthma parameters, respiratory function and systemic inflammation

miRNA

Variable

Univariate analysis

Multivariable analysis

Beta (95% CI)

p-value

Beta (95% CI)

p-value

Model statistics

miRNA-146a

Asthma status

0.01 (− 0.18 to 0.2)

0.92

0.02 (− 0.16 to 0.19)

0.86

R2 = 0.13, R2 Corr. = 0.11, F(3,111) = 5.5, p = 0.002

Age group

 − 0.28 (− 0.46 to − 0.11)

0.002

 − 0.28 (−  0.46 to 0.11)

0.002

Age group*asthma status

Chi2 = 6.27, p(LR) = 0.01

0.22 (0.05 to 0.4)

0.01

miRNA-126a

Asthma status

 − 0.09 (− 0.28 to 0.1)

0.35

 − 0.12 (− 0.29 to 0.05)

0.17

R2 = 0.22, R2 Corr. = 0.2, F(3,105) = 9.9, p < 0.001

Age group

 − 0.45 (− 0.62 to − 0.28)

 < 0.001

 − 0.46 (− 0.63 to - 0.29)

 < 0.001

Age group*asthma status

Chi2 = 0.001. p(LR) = 0.98

0 (− 0.17 to 0.17)

0.98

miRNA-106a

Asthma status

 − 0.12 (− 0.3 to 0.06)

0.2

 − 0.13 (− 0.3 to 0.05)

0,15

R2 = 0.12, R2 Corr. = 0.09, F(3,111) = 5, p = 0.003

Age group

 − 0.31 (− 0.49 to − 0.14)

 < 0.001

 − 0.32 (− 0.49 to  − 0.14)

 < 0.001

Age group*asthma status

Chi2 = 0.49. p(LR) = 0.49

 − 0.06 (− 0.24 to 0.12)

0.49

miRNA-19b

Asthma status

0.17 (− 0.01 to 0.35)

0.07

0.17 (− 0.01 to 0.35)

0.06

R2 = 0.13, R2 Corr. = 0.1, F(3,111) = 5.45, p = 0.002

Age group

 − 0.29 (− 0.47 to − 0.12)

0.001

 − 0.29 (− 0.46 to  − 0.11)

0.002

Age group*asthma status

Chi2 = 2.05, p(LR) = 0.15

0.13 (− 0.05 to 0.3)

0.16

  1. In the model, each tested miRNA was used as the dependent variable, while the independent variables were asthma status (asthma vs controls), age group (elderly vs. non-elderly), and age group*asthma status interaction. miRNA expression [2−ΔCt] was log-2 transformed before the analysis. The bold text indicates a statistically significant p-value