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Table 3 Univariate analysis of association of miRNAs expression with clinical and demographic characteristics in asthmatics and in groups stratified according to age

From: Circulating miRNA expression in asthmatics is age-related and associated with clinical asthma parameters, respiratory function and systemic inflammation

miRNA Independent variables Asthmatics EA nEA
Beta (95% CI) p-value Beta (95% CI) p-value Beta (95% CI) p-value
miRNA-146a IL-8 0.18 (− 0.1 − 0.45) 0.2 0.26 (− 0.17 to 0.69) 0.22 0.14 (− 0.24 to 0.52) 0.46
sTNF RI  − 0.18 (− 0.45 to 0.1) 0.2 0 (− 0.44 to 0.44) 0.99  − 0.35 (− 0.7 to 0.01) 0.054
IL-6  − 0.03 (− 0.3 to 0.25) 0.85 0.17 (− 0.25 to 0.58) 0.41  − 0.24 (− 0.62 to 0.13) 0.19
TNFα  − 0.16 (− 0.45 to 0.13) 0.27  − 0.17 (− 0.61 to 0.26) 0.42 0.03 (− 0.4 to 0.46) 0.88
Age 0.01 (− 0.26 to 0.28) 0.96 0.3 (− 0.11 to 0.7) 0.14 0.07 (− 0.31 to 0.45) 0.68
FEV1%/FVC 0.06 (− 0.21 to 0.34) 0.63 0.02 (− 0.41 to 0.45) 0.92 0.05 (− 0.33 to 0.43) 0.8
Sex 0.23 (− 0.03 to 0.5) 0.08 0.22 (− 0.19 to 0.63) 0.29 0.29 (− 0.07 to 0.65) 0.11
FeNO > 25 ppb 0.02 (− 0.25 to 0.3) 0.86  − 0.05 (− 0.49 to 0.39) 0.82 0.15 (− 0.23 to 0.52) 0.43
Atopy  − 0.13 (− 0.41 to 0.16) 0.38  − 0.13 (− 0.56 to 0.29) 0.53  − 0.23 (− 0.65 to 0.18) 0.26
BMI > 25 0.01 (− 0.26 to 0.28) 0.96 0.14 (− 0.28 to 0.56) 0.49  − 0.1 (− 0.48 to 0.28) 0.6
δR5–R20 > 20%  − 0.04 (− 0.31 to 0.23) 0.76 0.18 (− 0.25 to 0.6) 0.4  − 0.27 (− 0.64 to 0.09) 0.14
ACT < 20 0.07 (− 0.21 to 0.34) 0.63  − 0.05 (− 0.49 to 0.38) 0.8 0.32 (− 0.04 to 0.68) 0.08
miRNA-126a IL-8  − 0.24 (− 0.51 to 0.03) 0.09  − 0.06 (− 0.5 to 0.38) 0.79  − 0.18 (− 0.57 to 0.21) 0.35
sTNF RI  − 0.42 (− 0.68 to  −0.17) 0.001  − 0.21 (− 0.64 to 0.22) 0.33  − 0.28 (− 0.65 to 0.09) 0.13
IL-6  − 0.23 (− 0.5 to 0.04) 0.09  − 0.29 (− 0.69 to 0.12) 0.15  − 0.05 (− 0.45 to 0.34) 0.79
TNFα  − 0.34 (− 0.62 to  − 0.07) 0.02  − 0.44 (− 0.84 to  − 0.04) 0.03 0.24 (− 0.18 to 0.67) 0.25
Age  − 0.42 (− 0.67 to  − 0.17) 0.001  − 0.1 (− 0.52 to 0.32) 0.64 0.06 (− 0.33 to 0.44) 0.77
FEV1%/FVC 0.19 (− 0.08 to 0.46) 0.16  − 0.04 (− 0.46 to 0.38) 0.84  − 0.06 (− 0.44 to 0.33) 0.76
Sex 0.06 (− 0.21 to 0.33) 0.67 0.11 (− 0.31 to 0.53) 0.59  − 0.02 (− 0.4 to 0.37) 0.93
FeNO > 25 ppb 0.04 (− 0.23 to 0.32) 0.76  − 0.2 (− 0.62 to 0.22) 0.34 0.41 (0.06 to 0.76) 0.024
Atopy 0.19 (− 0.1 to 0.48) 0.2 0 (− 0.44 to 0.43) 0.98 0.11 (− 0.33 to 0.55) 0.6
BMI > 25  − 0.18 (− 0.45 to 0.09) 0.18  − 0.21 (− 0.62 to 0.2) 0.3 0.05 (− 0.34 to 0.44) 0.8
δR5-R20 > 20%  −  0.27 (− 0.53 to  − 0.003) 0.047  − 0.19 (− 0.61 to 0.23) 0.36  − 0.25 (− 0.62 to 0.13) 0.19
ACT < 20 0.02 (− 0.25 to 0.29) 0.89  − 0.24 (− 0.65 to 0.17) 0.23 0.55 (0.23 to 0.87) 0.002
miRNA-106a IL-8  − 0.25 (− 0.52 to 0.02) 0.07  − 0.07 (− 0.5 to 0.36) 0.74  − 0.32 (− 0.69 to 0.05) 0.08
sTNF RI  − 0.46 (− 0.7 to 0.21)  < 0.001  − 0.27 (− 0.69 to 0.14) 0.19  − 0.39 (− 0.74 to  − 0.04) 0.03
IL-6  − 0.11 (− 0.38 to 0.16) 0.41 0.07 (− 0.34 to 0.48) 0.73  − 0.19 (− 0.57 to 0.19) 0.32
TNFα  − 0.11 (− 0.4 to 0.18) 0.45  − 0.09 (− 0.52 to 0.34) 0.68 0.04 (− 0.39 to 0.47) 0.86
Age  − 0.38 (− 0.63 to  − 0.13) 0.003  − 0.26 (− 0.66 to 0.14) 0.19 0.14 (− 0.24 to 0.51) 0.46
FEV1%/FVC 0.23 (− 0.04 to 0.49) 0.09 0.09 (− 0.33 to 0.51) 0.65  − 0.03 (− 0.41 to 0.35) 0.87
Sex  − 0.15 (− 0.41 to 0.12) 0.27  − 0.35 (− 0.74 to 0.04) 0.07 0.17 (− 0.21 to 0.54) 0.91
FeNO > 25 ppb 0.15 (− 0.12 to 0.42) 0.26 0.06 (− 0.37 to 0.49) 0.77 0.42 (0.07 to 0.76) 0.02
Atopy  − 0.01 (− 0.3 to 0.27) 0.93  − 0.21 (− 0.62 to 0.2) 0.3  − 0.09 (− 0.52 to 0.34) 0.67
BMI > 25  − 0.17 (− 0.44 to 0.09) 0.19  − 0.07 (− 0.48 to 0.34) 0.72  − 0.07 (− 0.45 to 0.31) 0.7
δR5–R20 > 20%  − 0.17 (− 0.43 to 0.1) 0.22  − 0.13 (− 0.55 to 0.29) 0.53  − 0.01 (− 0.39 to 0.37) 0.95
ACT < 20 0.22 (− 0.04 to 0.49) 0.09 0.14 (− 0.27 to 0.56) 0.49 0.67 (0.39 to 0.95)  < 0.001
miRNA-19b IL-8 0.03 (− 0.25 to 0.31) 0.81 0.18 (− 0.26 to 0.61) 0.4  − 0.04 (− 0.43 to 0.35) 0.84
sTNF RI  − 0.11 (− 0.39 to 0.16) 0.42 0.11 (− 0.33 to 0.55) 0.6  − 0.25 (− 0.62 to 0.11) 0.17
IL-6  − 0.14 (− 0.41 to 0.13) 0.3  − 0.17 (− 0.59 to 0.24) 0.41 0.01 (− 0.38 to 0.39) 0.97
TNFα 0.04 (− 0.25 to 0.34) 0.77 0.08 (− 0.36 to 0.52) 0.72  − 0.13 (− 0.56 to 0.3) 0.54
Age  − 0.17 (− 0.44 to 0.1) 0.2 0.19 (− 0.23 to 0.6) 0.36  − 0.08 (− 0.46 to 0.3) 0.67
FEV1%/FVC 0.15 (− 0.11 to 0.42) 0.25 0.03 (− 0.4 to 0.46) 0.87 0.07 (− 0.31 to 0.45) 0.7
Sex  − 0.01 (− 0.28 to 0.26) 0.94  − 0.03 (− 0.45 to 0.39) 0.89 0 (− 0.38 to 0.38) 0.99
FeNO > 25 ppb 0.13 (− 0.14 to 0.41) 0.33 0.28 (− 0.14 to 0.7) 0.18  − 0.13 (− 0.51 to 0.24) 0.48
Atopy 0.06 (− 0.23 to 0.35) 0.68  − 0.08 (− 0.51 to 0.35) 0.7 0.1 (− 0.33 to 0.53) 0.62
BMI > 25 0.06 (− 0.21 to 0.33) 0.68 0.13 (− 0.29 to 0.55) 0.52 0.25 (− 0.12 to 0.62) 0.17
δR5–R20 > 20% 0.03 (− 0.24 to 0.31) 0.8 0.15 (− 0.27 to 0.58) 0.46  − 0.01 (− 0.39 to 0.37) 0.97
ACT < 20  − 0.22 (− 0.49 to 0.05) 0.1  − 0.22 (− 0.64 to 0.2) 0.3  − 0.2 (− 0.57 to 0.17) 0.28
  1. miRNA expression [2−ΔCt] and concentration of cytokines [pg/mL] were log-2 transformed before the analysis. Bold text indicates a statistically significant p-value
  2. EA elderly asthmatics, nEA non-elderly asthmatics, FeNO fractional exhaled Nitric Oxide, ACT Asthma Control Test, FEV1%FVC forced expiratory volume in one second/forced vital capacity ratio, δR5–20 Hz difference of resistance at 5 and 20 Hz, BMI body mass index