From: Serum urate and lung cancer: a cohort study and Mendelian randomization using UK Biobank
Smoking status | Sex stratified quintile of urate* | Number | Mean FEV1 (SD) | Lung cancer events | Person years (× 10,000 PYs) | Lung cancer incidence rate per 10,000 PYs (95%CI) |
---|---|---|---|---|---|---|
Overall | 1 | 71,720 | 2.93 (0.76) | 398 | 50.4 | 7.9 (7.2–8.7) |
2 | 71,895 | 2.90 (0.77) | 366 | 50.4 | 7.3 (6.6–8.0) | |
3 | 71,753 | 2.87 (0.78) | 325 | 50.6 | 6.4 (5.8–7.2) | |
4 | 71,932 | 2.83 (0.78) | 353 | 50.6 | 7.0 (6.3–7.7) | |
5 | 71,952 | 2.73 (0.79) | 482 | 50.6 | 9.5 (8.7–10.4) | |
Never | 1 | 41,109 | 2.96 (0.75) | 48 | 29.1 | 1.7 (1.2–2.2) |
2 | 40,528 | 2.94 (0.77) | 52 | 28.6 | 1.8 (1.4–2.4) | |
3 | 39,586 | 2.90 (0.78) | 51 | 28.0 | 1.8 (1.4–2.4) | |
4 | 38,387 | 2.85 (0.78) | 56 | 27.2 | 2.1 (1.6–2.7) | |
5 | 35,720 | 2.76 (0.79) | 56 | 25.2 | 2.2 (1.7–2.9) | |
Former | 1 | 21,764 | 2.92 (0.75) | 146 | 15.2 | 9.6 (8.2–11.3) |
2 | 23,463 | 2.89 (0.75) | 139 | 16.4 | 8.5 (7.2–10.0) | |
3 | 24,993 | 2.87 (0.76) | 142 | 17.5 | 8.1 (6.9–9.5) | |
4 | 26,584 | 2.82 (0.77) | 178 | 18.6 | 9.6 (8.3–11.1) | |
5 | 29,658 | 2.71 (0.78) | 288 | 20.7 | 13.9 (12.4–15.6) | |
Current | 1 | 8623 | 2.82 (0.82) | 204 | 6.0 | 34.0 (29.6–39.0) |
2 | 7656 | 2.79 (0.82) | 174 | 5.3 | 32.8 (28.3–38.0) | |
3 | 6953 | 2.77 (0.83) | 130 | 4.9 | 26.7 (22.5–31.7) | |
4 | 6727 | 2.76 (0.84) | 118 | 4.7 | 25.2 (21.0–30.2) | |
5 | 6278 | 2.66 (0.84) | 133 | 4.4 | 30.3 (25.6–35.9) |