Fig. 1

Efficacy of mepolizumab, by age at asthma onset, lung function, and airway reversibility. A Annualised rates of clinically significant exacerbations; B Change from baseline to study end in pre-bronchodilator FEV₁; C Change from baseline to study end in SGRQ total score; D Change from baseline to study end in ACQ-5 score. All plots are for patients receiving mepolizumab versus placebo. ACQ Asthma Control Questionnaire, CI confidence interval, FEV₁ forced expiratory volume in 1 sm ITT intent-to-treat, SGRQ St George’s Respiratory Questionnaire