Fig. 2

Airway responsiveness to inhaled methacholine. Resistance of the respiratory system (Rrs), elastance (Ers), Newtonian resistance (Rn), tissue damping (G), and tissue elastance (H). a Baseline parameters in wild-type and ob/ob mice. Airway responsiveness in b non-treated wild-type and ob/ob mice, c non-treated, IL-33-treated, Leptin + IL-33-treated wild-type mice, and d non-treated, IL-33-treated, Leptin + IL-33-treated ob/ob mice. Data are expressed as mean ± standard error of the mean (SEM). n = 5–9 for each group. a **p < 0.01, ***p < 0.001 vs. wild-type mice. b–d All parameters are shown as a fold-change from baseline. Closed circle: non-treated wild-type mice. Open circle: non-treated ob/ob mice. Closed square: IL-33-treated wild-type mice. Open square: IL-33-treated ob/ob mice. Closed triangle: Leptin + IL-33-treated wild-type mice. Open triangle: Leptin + IL-33-treated ob/ob mice. *p < 0.05, **p < 0.01 vs. non-treated. ^#p < 0.05, ^##p < 0.01, ^### vs. p < 0.001 vs. IL-33-treated