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Table 3 Univariate correlations between sputum e-DNA concentrations and lung physiology characteristics

From: Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma

Lung physiology characteristics Spearman's correlation coefficient (ρ) P value
FEV1, % − 0.18 0.036
FVC, % − 0.11 0.19
FEV1/FVC, % − 0.14 0.11
FEF50, % − 0.18 0.031
FEF25–75, (l/s) − 0.16 0.06
R5-20, % 0.15 0.09
X5Hz, KPa/l/s − 0.16 0.06
RV, % 0.24 0.004
RV/TLC, % 0.26 0.002
sReff, % 0.10 0.26
LCI 0.32  < 0.001
  1. FEV1 forced expiratory volume in first second, FVC forced vital capacity, FEF50% and FEF25–75 mean forced expiratory flow at 50% and between 25 and 75% of the forced vital capacity, R20 proximal airway resistance at 20 Hz, R5-20 small airway resistance (total lung resistance – large airway resistance), X5 lung reactance at 5 Hz, RV residual volume, TLC total lung capacity, sReff specific effective airway resistance, LCI lung clearance index from multiple breath washout