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Table 3 Univariate correlations between sputum e-DNA concentrations and lung physiology characteristics

From: Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma

Lung physiology characteristics

Spearman's correlation coefficient (ρ)

P value

FEV1, %

− 0.18

0.036

FVC, %

− 0.11

0.19

FEV1/FVC, %

− 0.14

0.11

FEF50, %

− 0.18

0.031

FEF25–75, (l/s)

− 0.16

0.06

R5-20, %

0.15

0.09

X5Hz, KPa/l/s

− 0.16

0.06

RV, %

0.24

0.004

RV/TLC, %

0.26

0.002

sReff, %

0.10

0.26

LCI

0.32

 < 0.001

  1. FEV1 forced expiratory volume in first second, FVC forced vital capacity, FEF50% and FEF25–75 mean forced expiratory flow at 50% and between 25 and 75% of the forced vital capacity, R20 proximal airway resistance at 20 Hz, R5-20 small airway resistance (total lung resistance – large airway resistance), X5 lung reactance at 5 Hz, RV residual volume, TLC total lung capacity, sReff specific effective airway resistance, LCI lung clearance index from multiple breath washout
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Respiratory Research

ISSN: 1465-993X

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