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Table 1 Characteristics of healthy subjects and patients with asthma

From: Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma

Characteristic Healthy
(n = 28)
Asthma
(n = 134)
P-value
Age, years 41.4 ± 18 52.3 ± 12 0.002
Sex, % male 53 47 0.54
BMI, kg/m2 25.2 ± 3.8 27.6 ± 5.1 0.016
Smoking history % 0 23 0.005
Current smokers, % 0 9  < 0.001
Severe asthma, % 48
FEV1, % 102 83.5  < 0.001
FVC, % 110 105 0.67
FEV1/FVC, % 77.5 65.1  < 0.001
Blood cell counts, 103/µl
 Eosinophils 145 (90–182) 240 (140–450)  < 0.001
 Neutrophils 2770 (2435–3452) 4210 (3370–5960)  < 0.001
Sputum cell counts, %*
 Eosinophils 0.1 (0.0–0.30) 1.5 (0.4–7.0)  < 0.001
 Neutrophils 25.5 (14–51) 53.3 (32–71) 0.008
 Macrophages 67.2 (44–81) 31 (15–53) 0.003
  1. Data are reported in mean ± SD or median (interquartile range)
  2. BMI body mass index, FEV1 predicted forced expiratory volume in the 1 s, FVC forced vital capacity. Smoking history: current or former smokers with smoking history ≥ 10 pack years
  3. *Sputum cell counts percentage of non-squamous cells