Fig. 1

Angiotensin-converting enzyme 2 (ACE2) expression in epithelial brushings (a, c, e, f, i) and bronchial biopsies(b, d, g, h, j). Gene expression is reported in vst. Each symbol represents a single sample, generally there are two samples per subject, symbol shapes indicate the different subject groups as shown in the legend at the bottom using the definitions in the main text. Boxes illustrate the median 25th and 75th percentile, whiskers extend to the smallest or largest value that is at most 1.5 times the interquartile range from the hinge. P-values represent the results of testing for differential expression using DeSeq2. a–d, i–j Blue lines represent the best fit of the relation between ACE2 and post bronchodilator lung function measurements, the grey shaded area represents the 95% confidence interval of the fit (e–h)