Acute exacerbation of fibrotic hypersensitivity pneumonitis: incidence and outcomes

Respiratory Research

Table 4 Predictors of all-cause mortality in patients with fibrotic HP

Characteristics	Unadjusted model		Multivariable model
Characteristics	HR (95% CI)	p-value	HR (95% CI)	p-value
Age	1.043 (1.006–1.082)	0.023	1.105 (1.040–1.174)	0.001
Female sex	1.129 (0.558–2.285)	0.735
BMI	0.899 (0.815–0.992)	0.035	0.859 (0.738–1.000)	0.050
Ever smoker	0.767 (0.371–1.583)	0.472
Positive history of exposure to antigen	1.295 (0.531–3.156)	0.570
Pulmonary function test
FVC	0.973 (0.954–0.993)	0.008	1.011 (0.976–1.047)	0.548
DL_CO	0.956 (0.934–0.978)	< 0.001	0.960 (0.914–1.009)	0.108
TLC	0.958 (0.931–0.986)	0.003
BALF analysis
Neutrophil count	0.977 (0.917–1.041)	0.478
Lymphocyte count	0.977 (0.956–1.000)	0.046	0.973 (0.946–1.001)	0.061
UIP-like pattern on HRCT	2.519 (1.211–5.241)	0.013	0.878 (0.276–2.791)	0.825
Acute exacerbation	9.825 (4.846–19.917)	< 0.001	8.641 (3.388–22.040)	< 0.001

BALF bronchoalveolar lavage fluid, BMI body mass index, DL_CO diffusing capacity of the lung for carbon monoxide, FVC forced vital capacity, HP hypersensitivity pneumonitis, HR hazard ratio; HRCT high-resolution computed tomography, TLC total lung capacity, UIP usual interstitial pneumonia
We did not include TLC in the multivariable model, as it strongly correlated with FVC (correlation coefficient, r = 0.873; p < 0.001)

ISSN: 1465-993X