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Table 2 Comparison of baseline characteristics between RD and no-RD groups among patients with fibrotic HP

From: Acute exacerbation of fibrotic hypersensitivity pneumonitis: incidence and outcomes

Characteristics

RD

No RD

Total

AE

No AE

Patients

33

18

15

68

Age, years

65.0 [54.5;70.0]

62.5 [53.5;70.3]

59.0 [54.0;66.0]

62.0 [50.5;67.0]

Female sex

21 (63.6)

10 (55.6)

11 (73.3)

40 (58.8)

BMI, kg/m2

23.6 [20.4;26.8]

24.3 [21.9;26.8]

25.5 [23.4;28.0]

24.4 [22.7;27.1]

Smoking

 Ever smoker

11 (33.3)

7 (38.9)

4 (26.7)

27 (39.7)

 Smoking amount, pack-years

30.0 [15.0;35.0]

20.0 [15.0;30.0]

35.0 [9.1;35.0]

30 [12.5;45.0]

Positive history of exposure to antigen

27 (81.8)

15 (83.3)

12 (80.0)

58 (85.3)

Pulmonary function test (%pred.)

 FVC

63.8 ± 21.9

67.7 ± 23.4

59.2 ± 19.6

74.8 ± 14.0

 DLCO

50.8 ± 18.3

50.5 ± 21.7

51.2 ± 14.3

64.6 ± 14.4

 TLC

68.0 ± 16.6

71.9 ± 18.9

63.9 ± 13.3

76.2 ± 10.8

6 min-walk test

 Distance, m

405.0 [330.0;476.5]

400.0 [287.5;476.3]

460.0 [404.0;490.0]

460.0 [405.0;500.0]

 Lowest saturation, %

91.0 [87.5;94.0]

90.0 [87.8;93.3]

92.0 [88.0;95.0]

93.0 [90.0;95.0]

BALF analysis

 Total WBC, /μL

205.0 [130.0;335.0]

180.0 [132.5;252.5]

120.0 [80.0;275.0]

180.0 [115.0;340.0]

 Neutrophil, %

4.0 [1.3;6.8]

4.0 [1.0;6.8]

5.0 [1.0;10.0]

4.0 [1.5;6.5]

 Lymphocyte, %

18.0 [13.0;47.0]

17.5 [8.5;30.5]

31.0 [15.0;59.5]

18.0 [11.0;32.5]

 Lympho-dominance (lymphocyte > 20%)

11 (33.3)

5 (27.8)

6 (40.0)

31 (45.6)

UIP-like pattern on HRCT

20 (60.6)

15 (83.3)*,

5 (33.3)

36 (52.9)

Treatment

 No treatment

0 (0.0)

0 (0.0)

0 (0.0)

10 (14.7)

 Corticosteroid ± immunosuppressants

33 (100.0)

18 (100.0)

15 (100.0)

58 (85.3)

  1. Data are presented as mean ± standard deviation, median [interquartile range], or n (%)
  2. AE acute exacerbation, BALF bronchoalveolar lavage fluid, BMI body mass index, DLCO diffusing capacity of the lung for carbon monoxide, FVC forced vital capacity, HP hypersensitivity pneumonitis, HRCT high-resolution computed tomography, % pred. % of the predicted value, RD rapid deterioration, TLC total lung capacity, UIP usual interstitial pneumonia, WBC white blood cell
  3. *p < 0.05 vs no AE
  4. p < 0.05 vs no RD