Skip to main content
Fig. 6 | Respiratory Research

Fig. 6

From: RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma

Fig. 6

Female Balb/c mice were senitised with house dust mite (HDM) in complete Freunds adjuvant intraperitoneally on days 0 and 1 and subsequently challenged intratracheally with saline (N = 6) or HDM in saline (N = 8) on days 14 and 15. Anti-mouse IL-17 blocking antibody or isotype control (400 µg) was dosed intraperitoneally on day 13. Mice were sacrificed on day 16 and pressure–volume loops (a), and bronchioalveolar lavage fluid neutrophils (b), IL-22 (c), KC (d) and IL-17 (e) and airway hyperresponsiveness to acetylcholine (f) were measured. Data are expressed as mean ± SEM. Statistical analysis was performed using a non-parametric Kruskal–Wallis test with Dunn’s multiple comparison (*P < 0.05)

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us