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Table 4 Logistic regression analyses for different proET-1 cut-offs at different time points. Crude and adjusted association of different proET-1 cut-offs at different time points and 30-day mortality

From: Association of endothelial activation assessed through endothelin-I precursor peptide measurement with mortality in COVID-19 patients: an observational analysis

 

Survivors (n = 57)

Non-Survivors (n = 17)

p-value

AUC

Univariable ORc (95% CI), p-value

Multivariabla ORc (95% CI), p-value

Multivariableb ORc (95% CI), p-value

proET-1 Time point 0 (within 24 h form admission), n = 74

 proET-1 overall, median (IQR)

53.6 (37.0, 69.0)

81.8 (76.0, 118.0)

 < 0.01

0.74

1.2 (1.1 to 1.4), p < 0.01

1.1 (0.9 to 1.4), p = 0.12

0.9 (0.6 to 1.2), p = 0.35

 proET-1- 74.0-cut-off [pmol/L], n (%)

   ≤ 74.0

44 (77%)

4 (24%)

 < 0.01

 

Reference

Reference

Reference

   > 74.0

13 (23%)

13 (76%)

  

11.0 (3.1 to 39.6), p < 0.01

4.8 (1.0 to 22.0), p = 0.05

1.9 (0.3 to 13.0), p = 0.50

proET-1- 94.0-cut-off [pmol/L], n (%)

 ≤ 94.0

52 (91%)

12 (71%)

0.03

 

Reference

Reference

Reference

 > 94.0

5 (9%)

5 (29%)

  

4.3 (1.1 to 17.4), p = 0.04

2.6 (0.5 to 14.0), p = 0.27

1.0 (0.1 to 14.0), p = 0.99

  proET-1- 154.0-cut-off [pmol/L], n (%)

   ≤ 154.0

55 (96%)

15 (88%)

0.19

 

Reference

Reference

NA

   > 154.0

2 (4%)

2 (12%)

  

3.7 (0.5 to 28.2), p = 0.2

3.3 (0.3 to 38.2), p = 0.34

NA

 proET-1- median-cut-off [pmol/L], n (%)

   ≤ 106

52 (91%)

12 (71%)

0.03

 

Reference

Reference

Reference

   > 106

5 (9%)

5 (29%)

  

4.3 (1.1 to 17.4), p = 0.04

2.6 (0.5 to 14.0), p = 0.27

1.0 (0.07 to 14.0), p = 0.99

proET-1 Time point 1 (day 3/day 4 of hospitalization), n = 55

 proET-1 overall, median (IQR)

56.9 (44.5, 77.3)

124.3 (95.4, 156.0)

 < 0.01

0.81

1.2 (1.0 to 1.04), p < 0.01

1.2 (1.0 to 1.4), p = 0.03

1.3 (1.0 to 1.8), p = 0.76

 proET-1- 74.0-cut-off [pmol/L], n (%)

   ≤ 74.0

30 (70%)

2 (17%)

 < 0.01

 

Reference

Reference

Reference

   > 74.0

13 (30%)

10 (83%)

  

11.5 (2.2 to 60.2), p < 0.01

8.7 (1.5 to 52.3), p = 0.02

72.0 (1.0 to 5257.0), p = 0.05

 proET-1- 94.0-cut-off [pmol/L], n (%)

   ≤ 94.0

37 (86%)

3 (25%)

 < 0.01

 

Reference

Reference

Reference

   > 94.0

6 (14%)

9 (75%)

  

18.5 (3.9 to 88.5), p < 0.01

12.4 (2.2 to 68.3), p < 0.01

78.6 (1.0 to 5688.0), p = 0.05

 proET-1- 154.0-cut-off [pmol/L], n (%)

   ≤ 154.0

41 (95%)

9 (75%)

0.03

 

Reference

Reference

Reference

   > 154.0

2 (5%)

3 (25%)

  

6.8 (0.9 to 47.0), p = 0.05

6.2 (0.7 to 54.3), p = 0.10

68.0 (0.2 to 18,750.0), p = 0.14

 proET-1- median-cut-off [pmol/L], n (%)

   ≤ 63.4

27 (63%)

1 (8%)

 < 0.01

 

Reference

Reference

NA

   > 63.4

16 (37%)

11 (92%)

  

18.6 (2.2 to 157.5), p < 0.01

17.0 (1.8 to 160.7), p = 0.01

NA

proET-1 Time point 2 (day 5/day 6 of hospitalization), n = 45

 proET-1 overall, median (IQR)

54.0 (39.0, 91.2)

163.2 (107.2, 217.6)

 < 0.01

0.91

1.2 (1.0 to 1.4), p = 0.01

1.1 (1.0 to 1.3), p = 0.03

N/A

 proET-1- 74.0-cut-off [pmol/L], n (%)

   ≤ 74.0

26 (72%)

1 (11%)

 < 0.01

 

Reference

Reference

NA

   > 74.0

10 (28%)

8 (89%)

  

20.8 (2.3 to 188.3), p < 0.01

19.3 (1.6 to 238.0), p = 0.02

NA

 proET-1- 94.0-cut-off [pmol/L], n (%)

   ≤ 94.0

28 (78%)

1 (11%)

 < 0.01

 

Reference

Reference

NA

   > 94.0

8 (22%)

8 (89%)

  

28.0 (3.0 to 258.4), p < 0.01

25.2 (2.01 to 307.2), p = 0.01

NA

 proET-1- 154.0-cut-off [pmol/L], n (%)

   ≤ 154.0

33 (92%)

4 (44%)

 < 0.01

 

Reference

Reference

Reference

   > 154.0

3 (8%)

5 (56%)

  

13.8 (2.3 to 80.6), p < 0.01

9.8 (1.4 to 70.3), p = 0.02

15.6 (0.5 to 499.2), p = 0.12

 proET-1- median-cut-off [pmol/L], n (%)

   ≤ 59.5

23 (64%)

0 (0%)

 < 0.01

 

NA

NA

NA

   > 59.5

13 (36%)

9 (100%)

  

NA

NA

NA

proET-1 Time point 3 (day 7/day 8 of hospitalization), n = 31

 proET-1 overall, median (IQR)

56.5 (38.6, 101.7)

108.6 (97.8, 169.4)

0.04

0.8

1.1 (0.9 to 1.3), p = 0.06

1.1 (1.0 to 1.3), p = 0.12

1.2 (0.9 to 1.5), p = 0.16

 proET-1- 74.0-cut-off [pmol/L], n (%)

    ≤ 74.0

15 (58%)

0 (0%)

0.02

 

NA

NA

NA

   > 74.0

11 (42%)

5 (100%)

  

NA

NA

NA

 proET-1- 94.0-cut-off [pmol/L], n (%)

   ≤ 94.0

17 (65%)

1 (20%)

0.06

 

Reference

Reference

Reference

   > 94.0

9 (35%)

4 (80%)

  

7.6 (0.7 to 78.1), p = 0.09

4.6 (0.4 to 54.7), p = 0.23

11.3 (0.2 to 593.4), p = 0.23

 proET-1- 154.0-cut-off [pmol/L], n (%)

   ≤ 154.0

23 (88%)

3 (60%)

0.11

 

Reference

Reference

Reference

   > 154.0

3 (12%)

2 (40%)

  

5.1 (0.6 to 44.1), p = 0.14

2.6 (0.2 to 26.7), p = 0.43

3.6 (0.1 to 86.5), p = 0.43

 proET-1- median-cut-off [pmol/L], n (%)

   ≤ 81.65

16 (62%)

0 (0%)

0.01

 

NA

NA

NA

   > 81.65

10 (38%)

5 (100%)

  

NA

NA

NA

  1. Bold values indicate statistical significant
  2. AUC, area under the curve; CI, confidence interval; NA, not applicable; OR, odd ratio; proET-1, proEndothelin-1
  3. aAdjusted for age and gender
  4. bAdjusted for age, gender, creatinine level, diastolic blood pressure as well as cancer and coronary artery disease
  5. cOdds ratio for 10 pmol/L increase of proET-1
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Respiratory Research

ISSN: 1465-993X

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