Fig. 5
From: Mechanical ventilation enhances Acinetobacter baumannii-induced lung injury through JNK pathways
Acinetobacter baumannii (A.b.) instillation with S-methylisothiourea (SMT) injection before ventilation decreased the total cell number in BALF of WT mice. a SMT is used to investigate the role of iNOS in lung injury induced by A.b. instillation after ventilation. SMT treatment significantly decreased the total cell number in BALF, indicating that SMT injection before ventilation could prevent the inflammation in BALF. The production of nitrite in BALF b was inhibited by SMT injection at 1 h before ventilation and further decreased 30% by SMT injection at 2 h before ventilation. Also, the level of nitrite in serum c as decreased 50% by SMT injection at 1 h before ventilation and 65% by SMT injection at 2 h before ventilation respectively. BALF bronchoalveolar lavage fluid, MV mechanical ventilation, NS normal saline. *P < 0.05. n = 5–6/group