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Table 2 Univariate comparisons of clinical characteristics at the time of weaning from mechanical ventilation between successful and failed de-cannulation groups

From: Prediction of successful de-cannulation of tracheostomised patients in medical intensive care units

Characteristics

Successful de-cannulation (n = 149)

Failed de-cannulation (n = 197)

P value

Age, years

57.9 (41.0–74.8)

66.5 (52.6–80.4)

 < 0.001

Male

93 (62.4%)

138 (70.1%)

0.168

BMI, kg/m2

23.0 (19.0–27.0)

21.6 (17.5–25.7)

0.002

Underlying disease

 Malignant disease

 Respiratory disease

 Neurologic disease

 Genitourinary disease

 Cardiovascular disease

48 (32.2%)

22 (14.8%)

18 (12.1%)

19 (12.8%)

22 (14.8%)

87 (44.2%)

20 (10.2%)

54 (27.4%)

14 (7.1%)

30 (15.2%)

0.032

0.256

0.001

0.113

 > 0.999

Charlson co-morbidity index

3.9 (1.1–6.7)

5.0 (2.4–7.6)

 < 0.001

Cause of MV support

 Pneumonia

 Extra-pulmonary sepsis

 Coma

 Pulmonary oedema

 ARDS

 Exacerbation of ILD

 Post CPR

 Central airway obstruction

70 (47.0%)

24 (16.1%)

9 (6.0%)

10 (6.7%)

19 (12.8%)

4 (2.7%)

7 (4.7%)

6 (4.0%)

68 (34.5%)

38 (19.3%)

46 (23.4%)

7 (3.6%)

8 (4.1%)

1 (0.5%)

18 (9.1%)

11 (5.6%)

0.026

0.534

 < 0.001

0.274

0.005

0.220

0.171

0.680

Duration of MV, days

21.9 (2.2–39.6)

18.1 (0.3–38.0)

0.073

Charlson co-morbidity index

3.9 (1.1–6.7)

5.0 (2.4–7.6)

 < 0.001

SOFA score

2.7 (0.8–4.6)

4.6 (2.0–7.2)

 < 0.001

Positive CAM–ICU

48 (32.2%)

159 (80.7%)

 < 0.001

Change of GCS

Decreased

No change

Increased

18 (12.1%)

56 (37.6%)

75 (50.3%)

54 (27.4%)

71 (36.0%)

71 (36.0%)

0.001

0.855

0.011

Suction frequency within 24 h

8.0 (8.0–10.0)

14.0 (12.0–16.0)

 < 0.001

Weaning index

 Respiratory rate, /min

 PaO2/FiO2 ratio

 RSBI

20.0 (16.0–23.0)

350.0 (286.0–411.0)

43.0 (32.0–55.0)

19.0 (16.0–24.0)

311.0 (250.0–382.0)

49.0 (32.0–65.0)

0.848

0.001

0.059

Laboratory findings

 Total bilirubin, mg/dL

 Creatinine, mg/dL

 Lactic acid, mmol/L

0.9 (0.5–1.7)

0.9 (0.6–1.4)

1.1 (0.7–1.5)

0.6 (0.4–1.1)

0.7 (0.5–1.1)

1.7 (0.7–2.7)

 < 0.001

0.009

 < 0.001

Vasopressor requirement

5 (3.4%)

28 (14.2%)

0.001

CRRT

4 (2.7%)

7 (3.6%)

0.883

Post-tracheostomy pneumonia during MV

36 (24.2%)

88 (44.7%)

 < 0.001

  1. Data are presented as number (percentage) or as median (interquartile range)
  2. BMI body mass index, MV mechanical ventilation, ARDS, acute respiratory distress syndrome, ILD interstitial lung disease, CPR cardiopulmonary resuscitation, SOFA sequential organ failure assessment; CAM–ICU, confusion assessment method for the intensive care unit, GCS Glasgow coma scale, PaO2 partial pressure of oxygen, FiO2 fraction of inspired oxygen, RSBI rapid shallow breathing index, CRRT continuous renal replacement therapy