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Table 1 Baseline characteristics

From: Impact of bronchoalveolar lavage lymphocytosis on the effects of anti-inflammatory therapy in idiopathic non-specific interstitial pneumonia, idiopathic pleuroparenchymal fibroelastosis, and unclassifiable idiopathic interstitial pneumonia

 

Anti-inflammatory drugs

P value

n

No (n = 63)

Yes (n = 123)

Male sex

46 (73.0)

70 (56.9)

0.047

186

Age (year)

64.0 ± 9.3

61.7 ± 11.1

0.135

186

Never-smoker

27 (43.6)

59 (48.8)

0.609

183

Modified MRC

 0

25 (47.2)

32 (28.3)

0.117

166

 1

21 (39.6)

64 (56.6)

 2

6 (11.3)

14 (12.4)

 3

1 (1.9)

3 (2.7)

 4

0 (0.0)

0 (0.0)

6-min walk test

 Distance (m)

514.6 ± 152.9

476.1 ± 137.3

0.148

137

 Minimum SpO2 (%)

90.0 ± 5.5

89.2 ± 6.1

0.443

135

Respiratory function

 FVC % predicted (%)

83.9 ± 21.9

76.7 ± 17.5

0.025

185

 DLCO % predicted (%)

78.9 ± 24.5

64.3 ± 22.8

0.006

162

Laboratory examinations

 LDH (IU/L)

225.4 ± 81.8

242.2 ± 67.7

0.162

186

 KL-6 (U/mL)

1331 ± 1255

1874 ± 1873

0.020

186

 SP-D (ng/mL)

219.5 ± 176.3

316.0 ± 296.6

0.011

162

 PaO2/FiO2 ratio (mmHg)

410.8 ± 67.5

385.7 ± 50.1

0.014

174

BAL

 Total volume of retrieved fluid (%)

50.3 ± 12.2

48.7 ± 15.4

0.470

177

 Total cell count (× 105/mL)

2.0 ± 1.6

2.7 ± 2.0

0.012

178

 Neutrophils (%)

5.0 ± 11.9

6.2 ± 10.7

0.510

186

 Lymphocytes (%)

18.0 ± 19.4

20.9 ± 19.7

0.340

186

 Eosinophils (%)

3.1 ± 4.5

3.8 ± 5.5

0.365

186

 Macrophages (%)

73.6 ± 24.1

69.4 ± 24.5

0.266

186

 CD4+/CD8+ ratio

2.0 ± 1.9

1.7 ± 1.9

0.388

180

HRCT pattern in MDD

 Definite UIP

0 (0.0)

4 (3.3)

0.004

186

 Possible UIP

26 (41.3)

25 (20.3)

 Inconsistent with UIP

37 (58.7)

91 (76.4)

Pathological pattern

 Definite UIP

1 (1.7)

6 (4.0)

0.298

181

 Probable UIP

14 (23.3)

30 (24.8)

 Possible UIP

23 (38.3)

31 (25.6)

 Not UIP

22 (36.7)

54 (44.6)

Pathological features (none/mild/moderate/prominent)

 Fibroblastic foci

20/27/13/0

46/41/31/2

0.424

180

 Honeycombing

44/11/5/0

86/22/9/1

0.911

178

 Organizing pneumonia

45/10/4/1

65/18/24/11

0.013

178

 Bronchiolocentric fibrosis

27/26/6/0

76/35/4/0

0.020

174

 Lymphoid follicle

20/31/7/1

24/67/25/3

0.167

178

 Alveolar macrophages

11/33/15/0

15/80/25/0

0.346

179

 Interstitial cell infiltration

4/44/8/2

9/62/43/6

0.013

178

 Bronchiolitis

30/24/4/0

65/43/9/0

0.837

175

 Fibroelastosis

45/7/4/3

95/16/4/6

0.762

180

MDD diagnosis

 iNSIP

5 (7.9)

32 (26.0)

0.006

186

 iPPFE

8 (12.7)

8 (6.5)

 Unclassifiable IIP

50 (79.4)

83 (67.5)

IPAF

8 (12.7)

51 (41.5)

< 0.001

186

  1. BAL bronchoalveolar lavage, COP cryptogenic organizing pneumonia, DLCO diffusion capacity for carbon monoxide, FEV1 forced expiratory volume in 1 s, FiO2 fractional concentration of oxygen in inspired gas, FVC forced vital capacity, HRCT high-resolution computed tomography, IIP idiopathic interstitial pneumonia, IPAF interstitial pneumonia with autoimmune features, IPF idiopathic pulmonary fibrosis, KL-6 Krebs von den Lungen-6, LDH lactate dehydrogenase, MDD multidisciplinary discussion, MRC Medical Research Council, iNSIP idiopathic non-specific interstitial pneumonia, PaO2 partial pressure of oxygen in arterial blood, iPPFE idiopathic pleuroparenchymal fibroelastosis, SLB surgical lung biopsy, SP-D surfactant protein D, SpO2 percutaneous oxyhemoglobin saturation, TBE traction bronchiectasis, UIP usual interstitial pneumonia
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Respiratory Research

ISSN: 1465-993X

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