Table 4 Median 1-year decline in FVC%pred and DLCO%pred in subgroups of patients split by median values of baseline laboratory parameters
Laboratory parameter | Parameter of functional decline | High group | Low group | P value |
|---|---|---|---|---|
Monocyte count | Median ΔFVC%pred (derivation cohort), (95% CI) | 0.0 (− 2.8 to 1.9) | 0.1 (− 4.0 to 2.2) | 0.85 |
Median ΔFVC%pred (validation cohort), (95% CI) | − 2.4 (− 6.3 to 0.7) | − 0.8 (− 2.0 to 0.4) | 0.19 | |
Median ΔDLCO%pred (derivation cohort), (95% CI) | − 2.2 (− 4.7 to − 0.6) | − 2.8 (− 5.7 to -1.2) | 0.70 | |
Median ΔDLCO%pred (validation cohort), (95% CI) | − 3.5 (− 7.1 to − 1.3) | − 3.3 (− 5.5 to − 1.0) | 0.64 | |
RDW | Median ΔFVC%pred (derivation cohort), (95% CI) | 0.0 (− 2.7 to 1.9) | − 2.1 (− 4.5 to − 0.1) | 0.10 |
Median ΔFVC%pred (validation cohort), (95% CI) | − 0.3 (− 2.3 to 4.1) | − 1.9 (− 4.5 to − 0.1) | 0.08 | |
Median ΔDLCO%pred (derivation cohort), (95% CI) | − 2.1 (− 4.5 to − 0.1) | − 2.1 (− 5.4 to − 1.0) | 0.82 | |
Median ΔDLCO%pred (validation cohort), (95% CI) | − 3.0 (− 6.1 to 1.0) | − 3.5 (− 5.5 to 1.4) | 0.64 |