Table 3 Comorbidities of FASE-CPHG severe asthma clusters
Cluster 1 Early onset atopic (N = 690) | Cluster 2 Obese (N = 153) | Cluster 3 Late-onset (N = 299) | Cluster 4 Eosinophilic (N = 143) | Cluster 5 Aspirin-sensitivity (N = 139) | Patients analysed n = 1424 | p | ||
|---|---|---|---|---|---|---|---|---|
Fernand widal syndrome | Yes | 3 (0.4%) | 6 (3.9%) | 0 (0%) | 16 (11.2%) | 72 (51.8%) | 97 (6.8%) | < 0.0001 |
Food allergy | Yes | 78 (11.3%) | 17 (11.1%) | 12 (4%) | 14 (9.8%) | 25 (18%) | 146 (10.3%) | < 0.01 |
Drug allergy | Yes | 69 (10%) | 28 (18.3%) | 35 (11.7%) | 15 (10.5%) | 54 (38.8%) | 201 (14.1%) | < 0.0001 |
Atopic dermatitis | Yes | 130 (18.8%) | 18 (11.8%) | 19 (6.4%) | 19 (13.3%) | 33 (23.7%) | 219 (15.4%) | < 0.0001 |
Allergic broncho-pulmonary aspergillosis | Yes | 22 (3.2%) | 2 (1.3%) | 6 (2%) | 1 (0.7%) | 5 (3.6%) | 36 (2.5%) | 0.28 |
Vascularitis | Yes | 6 (0.9%) | 1 (0.7%) | 5 (1.7%) | 3 (2.1%) | 0 (0%) | 15 (1.1%) | 0.33 |
Diabetus | Yes | 46 (6.7%) | 35 (23%) | 42 (14.1%) | 7 (4.9%) | 11 (8%) | 141 (10%) | < 0.0001 |
Ischemic cardiopathy | Yes | 22 (3.2%) | 16 (10.5%) | 17 (5.7%) | 9 (6.3%) | 6 (4.3%) | 70 (4.9%) | < 0.001 |
Osteoporosis | Yes | 58 (8.4%) | 17 (11.1%) | 36 (12.1%) | 23 (16.1%) | 19 (13.7%) | 153 (10.8%) | 0.16 |
Anxiety (HAD-A) | Means (Sd) | 7.6 (± 4.5) | 7.5 (± 4.5) | 7.3 (± 4.2) | 7 (± 4.4) | 7.1 (± 4.7) | 7.4 (± 4.4) | 0.52 |
Depression (HAD-D) | Means (Sd) | 4.6 (± 3.6) | 5.6 (± 4.1) | 5.4 (± 3.9) | 5.3 (± 4.2) | 5.3 (± 3.7) | 5 (± 3.8) | < 0.01 |
Number of comorbidities (outside ENT) | 0 | 247 (35.8%) | 0 (0%) | 57 (19.1%) | 47 (32.9%) | 27 (19.4%) | 378 (26.6%) | |
1 | 212 (30.8%) | 24 (15.7%) | 92 (30.9%) | 52 (36.4%) | 42 (30.2%) | 422 (29.7%) | ||
2 | 120 (17.4%) | 33 (21.6%) | 75 (25.2%) | 23 (16.1%) | 33 (23.7%) | 284 (20%) | ||
3 or more | 110 (16%) | 96 (62.7%) | 74 (24.8%) | 21 (14.7%) | 37 (26.6%) | 338 (23.8%) | ||