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Fig. 5 | Respiratory Research

Fig. 5

From: Relationship between long non-coding RNA PCAT-1 expression and gefitinib resistance in non-small-cell lung cancer cells

Fig. 5

PCAT-1 knockdown mediates gefitinib sensitivity through targeting the PI3K/AKT pathway. a The effects of PCAT-1 knockdown on the PI3K/Akt pathway. PCAT-1 knockdown inhibited AKT (b), P13K (c), and GSK3 (d) phosphorylation in H1299/GR cells. PCAT-1 knockdown-mediated gefitinib sensitivity was reversed in H1299/GR cells after PI3K/AKT agonist treatment, as measured by CCK8 (e and colony formation assays (f). *, p < 0.05, **, p < 0.01

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Respiratory Research

ISSN: 1465-993X

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