Fig. 9

Effects of exogenous H₂O₂ and NAC intervention on the constriction of PA and AA rings. A The effects of exogenous H₂O₂ on the constriction of PA and AA rings was biphasic (a, c) the representative curve for the effect of 5 ~ 1000 μM exogenous H₂O₂ on the the constriction of PA and AA rings (b, d) the summarized data of PA and AA rings maximum constriction, the constriction of PA ring increased in a dose-dependent manner by 5 ~ 400 μM H₂O₂ and was gradually inhibited by 600 ~ 1000 μM H₂O₂, the constriction of AA ring increased in a dose-dependent manner by 5 ~ 600 μM H₂O₂ and was gradually inhibited by 800 ~ 1000 μM H₂O₂. B 10 mM NAC effectively inhibited the constriction of PA and AA rings (a, b, d, e) the representative curve for the effect of H₂O₂ and NAC intervention on the constriction of PA and AA rings (c, f) the summarized data of PA and AA rings maximum vasodilation, n = 5, Data are means ± S.D. **P < 0.01 vs. 400 μM H₂O₂, ^##P < 0.01 vs. 600 μM H₂O₂