Fig. 10
Effects of NAC intervention on the proliferation of PASMCs and AASMCs and the constriction of PA and AA rings. A NAC inhibited the proliferation of PASMCs (a) and AASMCs (b) co-cultured with AECs in hypoxia. The growth of PASMCs and AASMCs in 21% O2 was set as 100% and the proliferation of treated cells was calculated as a percentage of them. P = PASMCs, A = AASMCs, n = 8, Data are means ± S.D. &P < 0.05 vs. P (21%O2), **P < 0.01 or *P < 0.05 vs. P (5%O2) or A (5% O2), ##P < 0.01 vs. P + ATII or A + ATII. B NAC inhibited the constriction of PA and AA rings (a, b, d, e) the representative curve for the effect of NAC intervention on the constriction of PA and AA induced by AECs hypoxic culture medium (c, f) the summarized data of PA and AA rings maximum constriction. AHCM ATII hypoxic culture medium, n = 5, Data are means ± S.D. **P < 0.01 vs. AHCM