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Table 3 P-mtDNA and disease progression at 3-year follow-up

From: Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort

 

Unadjusted

Adjusted for age & smoking status

\(r\)(CI)*

\(r\)(CI)*

FEV1% predicted

  

 Alla

0.04 (− 0.05, 0.14)

0.04 (− 0.06, 0.14)

  Males

0.08 (− 0.05, 0.22)

0.09 (− 0.05, 0.23)

  Females

0 (− 0.14, 0.13)

− 0.01 (− 0.15, 0.13)

6MWD (meters)

  

 All

− 0.04 (− 0.14, 0.07)

− 0.02 (− 0.12, 0.08)

  Males

0 (− 0.13, 0.13)

0.03 (− 0.11, 0.17)

  Females

− 0.08 (− 0.23, 0.07)

− 0.07 (− 0.23, 0.08)

SGRQ

  

 All

− 0.05 (− 0.16, 0.06)

− 0.06 (− 0.18, 0.05)

  Males

− 0.05 (− 0.19, 0.10)

− 0.07 (− 0.22, 0.08)

  Females

− 0.06 (− 0.22, 0.10)

− 0.06 (− 0.23, 0.10)

CAT

  

 All

0.01 (− 0.09, 0.11)

0 (− 0.09, 0.10)

  Males

0.01 (− 0.12, 0.13)

− 0.01 (− 0.15, 0.12)

  Females

0.02 (− 0.13, 0.16)

0.02 (− 0.12, 0.17)

  1. aAdjusting for age, sex, and smoking status
  2. r correlation coefficient, CI 95% confidence interval, FEV1 forced expiratory volume in 1 s, 6MWD six-minute walk distance, SGRQ St. George’s Respiratory Questionnaire, CAT COPD Assessment Test
  3. *Pearson’s correlation coefficients with log2 p-mtDNA as among all participants and within each group