Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort

Zhang, William Z.; Hoffman, Katherine L.; Schiffer, Kristen T.; Oromendia, Clara; Rice, Michelle C.; Barjaktarevic, Igor; Peters, Stephen P.; Putcha, Nirupama; Bowler, Russell P.; Wells, J. Michael; Couper, David J.; Labaki, Wassim W.; Curtis, Jeffrey L.; Han, Meilan K.; Paine, Robert; Woodruff, Prescott G.; Criner, Gerard J.; Hansel, Nadia N.; Diaz, Ivan; Ballman, Karla V.; Nakahira, Kiichi; Choi, Mary E.; Martinez, Fernando J.; Choi, Augustine M. K.; Cloonan, Suzanne M.

doi:10.1186/s12931-021-01707-x

Respiratory Research

Table 2 P-mtDNA and disease progression at 1-year follow-up

From: Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort

	Unadjusted	Adjusted for age & smoking status
	\(r\)(CI)*	\(r\)(CI)*
FEV₁% predicted
All^a	0 (− 0.08, 0.07)	− 0.01 (− 0.09, 0.06)
Males	− 0.01 (− 0.1, 0.09)	− 0.01 (− 0.12, 0.09)
Male smokers	− 0.08 (− 0.25, 0.1)	− 0.08 (− 0.27, 0.1)
Male mild/mod	− 0.03 (− 0.23, 0.17)	− 0.05 (− 0.26, 0.15)
Male severe	0.15 (− 0.07, 0.36)	0.14 (− 0.08, 0.35)
Females	0 (− 0.11, 0.11)	− 0.01 (− 0.12, 0.1)
Female smokers	0.04 (− 0.16, 0.23)	0.04 (− 0.16, 0.23)
Female mild/mod	− 0.09 (− 0.32, 0.15)	− 0.11 (− 0.35, 0.13)
Female severe	0.10 (− 0.16, 0.36)	0.08 (− 0.18, 0.34)
6MWD (meters)
All^a	− 0.02 (− 0.1, 0.06)	− 0.01 (− 0.09, 0.07)
Males	0.03 (− 0.07, 0.14)	0.04 (− 0.07, 0.15)
Male smokers	− 0.01 (− 0.19, 0.16)	− 0.01 (− 0.18, 0.16)
Male mild/mod	− 0.06 (− 0.28, 0.16)	− 0.05 (− 0.27, 0.16)
Male severe	0.27 (0.06, 0.48)^b	0.27 (0.05, 0.48)
Females	− 0.09 (− 0.21, 0.03)	− 0.09 (− 0.21, 0.04)
Female smokers	0.03 (− 0.17, 0.22)	0.03 (− 0.17, 0.22)
Female mild/mod	0.08 (− 0.16, 0.32)	0.08 (− 0.16, 0.32)
Female severe	− 0.33 (− 0.61, − 0.05)^c	− 0.30 (− 0.59, − 0.02)
SGRQ
All^a	− 0.02 (− 0.1, 0.07)	− 0.03 (− 0.12, 0.06)
Males	− 0.02 (− 0.13, 0.09)	− 0.04 (− 0.16, 0.08)
Male smokers	− 0.07 (− 0.27, 0.13)	− 0.1 (− 0.3, 0.1)
Male mild/mod	0 (− 0.2, 0.2)	0 (− 0.2, 0.2)
Male severe	− 0.14 (− 0.39, 0.1)	− 0.16 (− 0.41, 0.08)
Females	− 0.02 (− 0.14, 0.11)	− 0.01 (− 0.14, 0.11)
Female smokers	− 0.15 (− 0.38, 0.08)	− 0.15 (− 0.38, 0.08)
Female mild/mod	0.08 (− 0.2, 0.35)	0.10 (− 0.18, 0.37)
Female severe	− 0.02 (− 0.29, 0.25)	− 0.10 (− 0.39, 0.18)
CAT
All^a	− 0.07 (− 0.15, 0.01)	− 0.07 (− 0.15, 0.02)
Males	− 0.01 (− 0.11, 0.09)	− 0.01 (− 0.11, 0.1)
Male smokers	0.01 (− 0.16, 0.19)	0.04 (− 0.14, 0.21)
Male mild/mod	− 0.08 (− 0.29, 0.13)	− 0.08 (− 0.29, 0.12)
Male severe	− 0.05 (− 0.26, 0.17)	− 0.05 (− 0.27, 0.17)
Females	− 0.15 (− 0.28, − 0.02)	− 0.14 (− 0.27, − 0.01)
Female smokers	− 0.28 (− 0.5, − 0.06)	− 0.30 (− 0.52, − 0.08)
Female mild/mod	− 0.29 (− 0.54, − 0.03)	− 0.27 (− 0.52, − 0.01)
Female severe	0.05 (− 0.21, 0.31)	0.03 (− 0.22, 0.29)

r correlation coefficient, CI 95% confidence interval, FEV₁ forced expiratory volume in 1 s, 6MWD six-minute walk distance, SGRQ St. George’s Respiratory Questionnaire, CAT COPD Assessment Test
*Pearson’s correlation coefficients with log2 p-mtDNA as among all participants and within each group
^aAdjusting for age, sex, and smoking status
^bItalic—statistically significant with positive correlation coefficient
^cBold—statistically significant with negative correlation coefficient

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ISSN: 1465-993X

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