Copeptin, pro-atrial natriuretic peptide and pro-adrenomedullin as markers of hypoxic stress in patients with obstructive sleep apnea—a prospective intervention study

Table 4 Correlations between biomarker levels at baseline and various sleep parameters in patients with OSA

Correlation of	With	N	rho	p-value
Copeptin	ODI	142	0.105	0.214
proANP		142	− 0.054	0.526
proADM		142	0.101	0.233
Copeptin	Oxygen saturation at rest	141	− 0.133	0.116
proANP		141	− 0.095	0.261
proADM		141	− 0.053	0.535
Copeptin	Mean saturation	144	− 0.146	0.080
proANP		144	− 0.221	0.008
proADM		144	− 0.312	< 0.001
Copeptin	Hypoxemia duration	139	0.105	0.218
proANP		139	0.115	0.177
proADM		139	0.297	< 0.001
Copeptin	AHI	145	0.153	0.067
proANP		145	0.077	0.359
proADM		145	0.154	0.064
Copeptin	PLMI	90	0.045	0.677
proANP		90	0.120	0.261
proADM		90	0.259	0.014
Copeptin	Sleep latency	95	− 0.216	0.035
proANP		95	− 0.052	0.618
proADM		95	0.006	0.951
Copeptin	Sleep efficiency	94	0.198	0.055
proANP		94	− 0.155	0.135
proADM		94	− 0.250	0.015
Copeptin	VAS-general well being	70	0.133	0.271
proANP		70	0.033	0.789
proADM		70	0.054	0.659
Copeptin	ESS	144	0.010	0.906
proANP		144	0.057	0.498
proADM		144	− 0.033	0.692
Copeptin	BMI	143	0.156	0.063
proANP		143	− 0.103	0.219
proADM		143	0.336	< 0.001

ODI Oxygen Desaturation Index, AHI Apnea Hypopnea Index, PLMI Periodic Limb Movements of Sleep, VAS Visual Analogue Scale, ESS Epworth Sleepiness Scale, BMI Body Mass Index, rho Spearman Correlation coefficient

ISSN: 1465-993X