Frequency and functional translation of low muscle mass in overweight and obese patients with COPD

Machado, Felipe V. C.; Spruit, Martijn A.; Groenen, Miriam T. J.; Houben-Wilke, Sarah; van Melick, Paula P.; Hernandes, Nidia A.; Schols, Annemie M. W. J.; Pitta, Fabio; Wouters, Emiel F. M.; Franssen, Frits M. E.

doi:10.1186/s12931-021-01689-w

Respiratory Research

Table 1 Characteristics of COPD patients with normal and low FFMI according to age-sex BMI-specific cut-offs, after stratification into BMI categories

From: Frequency and functional translation of low muscle mass in overweight and obese patients with COPD

BMI group	Normal weight (n=206)		Overweight (n=157)		Obese (n=106)
FFMI group	Normal (n=88)	Low (n=118)	Normal (n=66)	Low (n=91)	Normal (n=61)	Low (n=45)
Subjects, % males	49.0	52.5	50.0	67.0*	44.3	66.7*
Age, y	64 ± 10	64 ± 8	65 ± 9	65 ± 10	64 ± 8	64 ± 9
BMI, kg m^-2	22.3 ± 1.8	21.6 ± 1.7†	27.7 ± 1.5	27.0 ± 1.2†	34.4 ± 2.9	31.7 ± 1.8#
FFMI, kg m^-2	17.2 [15.2–18.0]	14.5 [13.8–16.3]#	19.0 [16.4–19.6]	17.1 [15.5–18.2]#	20.4 [18.6–21.8]	19.1 [16.5–20.1]#
FEV₁, l	1.10 [0.83–1.44]	0.92 [0.68–1.41]	1.33 [0.96–1.90]	1.13 [0.77–1.72]	1.32 [0.99–1.74]	1.45 [1.04–1.92]
FEV₁, %pred	44.5 [34–55.6]	37.3 [27.4–51.1]†	55.6 [41.9–69.4]	41.0 [32.0–65.7]*	56.0 [41.4–70.3]	53.5 [42.6–63.2]
FEV₁/FVC, %	32.6 [27.8–41.3]	30.8 [25.2–41.2]	40.3 [32.0–48.2]	33.0 [25.6–44.7]*	44 [34.7–53.4]	41.6 [33.5–49.2]
TLCO, %pred	45.5 [37–57.8]	40.3 [32.0–48.5]†	46.6 [38.0–63.0]	48.1 [40.9–61.1]	57.3 [49.5–68.8]	50.8 [42.0–60.1]*
mMRC, % grade ≥ 2	70.4	87.3†	81.8	75.8	86.7	82.2
6MWD, m	458 ± 121	410 ± 122†	434 ± 118	414 ± 126	402 ± 108	430 ± 118
6MWD, %pred	70 ±17	62 ± 18#	70 ± 17	67 ±17	70 ± 17	69 ± 16
Wmax, W	63 [49–87]	53 [41–68]†	69 [54–97]	64 [48–83]	66 [55–86]	75 [54–97]
Wmax, %pred	52 [38–73]	42 [31–61]†	55 [44–76]	48 [37–64]*	59 [41–91]	53 [43–65]
VO₂max, ml m^-1	998 [805–1234]	811 [661–978]#	1108 [872– 1349]	1088 [900–1291]	1126 [892–1368]	1267 [974–1542]
VO₂max, %pred	57 [47–78]	50 [36–73]*	67 [51–86]	58 [48–77]	81 [55–112]	64 [54–75]*
CWRT, s	267 [184–351]	190 [149–269]#	250 [173–343]	218 [176–302]	243 [172–445]	254 [171–410]
Quadriceps PT, Nm	87 ± 26	77 ± 29†	105 ± 37	95 ± 32	107 ± 38	108 ± 42
Quadriceps PT, %pred	64 ± 17	55 ± 14#	75 ± 17	65 ± 18†	79 ± 15	72 ± 21*
SGRQ Total score, pts	59 [39–75]	63 [50–75]	62 [49–73]	63 [49–73]	68 [57–75]	63 [52–73]
HADS Anxiety score, pts	7 [4–11]	6 [4–11]	8 [5–13]	6 [4–10]	7 [5–12]	8 [4–12]
HADS Depression score, pts	7 [3–11]	6 [3–10]	7 [4–11]	7 [4–10]	8 [5–10]	6 [4–11]
ASMI, kg m^-2	6.58 ± 0.80	5.73 ± 0.77*	7.18 ± 1.06	6.67 ± 0.91*	7.98 ± 1.13	7.50 ± 1.10*
Lumbar spine, T-score	− 1.29 ± 1.38	− 1.09 ± 1.69	− 0.74 ± 1.37	− 0.99 ± 1.66	− 0.68 ± 1.27	− 0.87 ± 1.64
Hip, T-score	− 1.56 ± 1.00	− 1.86 ± 0.95*	− 1.69 ±0.90	− 1.67 ± 1.00	− 1.15 ± 1.06	− 1.19 ± 0.91

Mean ± standard deviation, median [interquartile range 25–75%] or frequency reported. ASMI appendicular skeletal muscle mass index; BMI body mass index; FFMI fat-free mass index; FEV₁ forced expiratory volume in the first second; FVC forced vital capacity; TLCO transfer factor for carbon monoxide; mMRC modified Medical Research Council; 6MWD six-minute walking distance; Wmax peak load during cycle ergometry; VO₂max peak oxygen uptake during cycle ergometry; CWRT time during constant work rate test; PT peak torque; SGRQ St George’s Respiratory Questionnaire; HADS hospital anxiety and depression questionnaire. *P < 0.05 versus normal FFMI from the same BMI group. †P < 0.01 versus normal FFMI from the same BMI group. #P < 0.001 versus normal FFMI from the same BMI group

Back to article page

ISSN: 1465-993X

Contact us

General enquiries: journalsubmissions@springernature.com