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Fig. 2 | Respiratory Research

Fig. 2

From: Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD

Fig. 2

More severe airflow obstruction is associated with lower plasma and serum sRAGE in multiple cohorts and with different assay platforms for sRAGE. sRAGE is shown on the log-scale y-axis. Shown are the QBR assays for COPDGene (n = 1437) (a) and ECLIPSE (n = 2342) (b), DuoSet for sRAGE assay for SCCOR (n = 399) (c), and RBM assay for R&D SPIROMICS (n = 1620) (d). Median, 25th percentile, 75th percentile, and whiskers (the minimum of 1.5 times interquartile range (IQR) or highest/lowest value) are shown in the box plots. e Forest plot of sRAGE effect size estimates for baseline FEV1 for each cohort (squares) as well as a weighted estimate of the meta-analysis (diamond). The shaded represents the interquartile range and the whiskers represent the 95% confidence interval. f Forest plot of sRAGE effect size estimates with FEV1 decline for each cohort (squares) as well as a weighted estimate of the meta-analysis (diamond). The shaded represents the interquartile range and the whiskers represent the 95% confidence interval

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