Single cell RNA sequencing identifies IGFBP5 and QKI as ciliated epithelial cell genes associated with severe COPD

Table 6 GSEA enrichment of the different clusters with the 127 gene signature

Cluster	ES	NES	NOM p-val	FDR q-val	FWER p-val
Ciliated	0.33	1.33	0.00	0.09	0.00
Cytotoxic T	0.33	1.29	0.00	0.09	0.00
Low quality T cells	0.47	1.29	0.00	0.11	0.00
AT2	0.39	1.27	0.09	0.18	0.04
Fibroblasts	0.40	1.31	0.10	0.18	0.05
T cells	0.31	1.17	0.10	0.21	0.05
Proliferative macrophages	0.37	1.23	0.10	0.22	0.05
B cells	− 0.24	− 0.97	0.18	0.28	0.09
NK	0.31	1.05	0.29	0.37	0.14
AT1	0.33	1.00	0.43	0.52	0.22
Monocytes	0.20	0.84	0.68	0.77	0.36
Macrophages	− 0.22	− 0.92	0.70	0.83	0.37
Club	− 0.20	− 0.82	0.76	0.88	0.39
Low quality	− 0.25	− 0.78	0.88	1.00	0.43
Endothelial	− 0.17	− 0.53	0.89	1.00	0.44
Mast cells	0.28	0.77	0.92	1.00	0.47

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