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Table 2 Characteristics of patients with IPF at the time of SLB

From: Exposure to PM2.5 is a risk factor for acute exacerbation of surgically diagnosed idiopathic pulmonary fibrosis: a case–control study

  All Acute exacerbation No acute exacerbation
Subjects 152 41 111
Case or control months 5,783 41 5,742
Age (years) 65 [61–70] 68 [63–71] 65 [60–70]
Male 106 (70%) 29 (71%) 77 (69%)
Pack-years 30 [0–45] 30 [0–53] 26 [0–45]
Pulmonary function tests    
 FVC (% predicted) 83.9 [75.1–96.4] 83.6 [75–92.2] 85.2 [75.2–97.2]
 DLCO (% predicted) 71.6 [55.5–85.6] 61.0 [48.5–75.9] 74.8 [57.2–88.4]
HRCT pattern    
 UIP 23 (15%) 9 (22%) 14 (13%)
 Possible UIP 122 (80%) 30 (73%) 92 (83%)
 Inconsistent with UIP 7 (5%) 2 (5%) 5 (4%)
Antifibrotic therapy    
 Pirfenidone 55 (36%) 18 (44%) 37 (33%)
 Nintedanib 19 (13%) 3 (7%) 16 (14%)
  1. Data presented as median [interquartile rage] or frequencies (%)
  2. IPF idiopathic pulmonary fibrosis, SLB surgical lung biopsy, FVC forced vital capacity, DLCO diffusing capacity of the lung for carbon monoxide, HRCT high-resolution computed tomography