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Table 3 Test characteristics of CT categories for histopathologic UIP

From: Practical application and validation of the 2018 ATS/ERS/JRS/ALAT and Fleischner Society guidelines for the diagnosis of idiopathic pulmonary fibrosis

 

UIP

Probable UIP

Indeterminate for UIP

Alternative diagnosis

PPV

0.87 (0.60, 0.98)

0.38 (0.14, 0.68)

0.27 (0.06, 0.61)

0.21 (0.11, 0.33)

NPV

0.76 (0.65, 0.84)

0.67 (0.56, 0.77)

0.66 (0.55, 0.76)

0.45 (0.29, 0.62)

Sensitivity

0.38 (0.22, 0.56)

0.15 (0.05, 0.31)

0.09 (0.02, 0.24)

0.38 (0.22, 0.56)

Specificity

0.97 (0.90, 1.00)

0.88 (0.78, 0.95)

0.90 (0.80, 0.96)

0.25 (0.16, 0.37)

  1. Test characteristics, including positive predictive value (PPV; e.g., Pr(histologic UIP|CT UIP)), negative predictive value (NPV; e.g., Pr(not histologic UIP|not CT UIP)), sensitivity (e.g., Pr(CT UIP|histologic UIP)), and specificity (e.g., Pr(not CT UIP| not histologic UIP)) were determined for all CT categories against histopathologic UIP. To quantify the uncertainty of these estimates, 95% confidence intervals were computed