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Fig. 6 | Respiratory Research

Fig. 6

From: IL-4Rα blockade reduces influenza-associated morbidity in a murine model of allergic asthma

Fig. 6

Systemic blockade of interleukin-4 receptor alpha (IL-4Rα) reduces house dust mite (HDM)-mediated excessive weight loss following pandemic H1N1 (pH1N1) infection. Mice were intranasally exposed to HDM for three consecutive weeks, and a single intranasal inoculation of pH1N1 was performed on day 0. Mean change in body mass is plotted as a percentage of weight on day 0 for a mice receiving IL-4Rα blockade (n = 13) or IgG (n = 12) through a prophylactic strategy (pooled from four independent experiments) and b mice receiving IL-4Rα blockade (n = 12) or IgG (n = 12) through a therapeutic strategy (pooled from two independent experiments). Data are expressed as mean ± SEM, and were compared using a two-way ANOVA with a Bonferroni correction. *P < 0.05, **P < 0.01, ****P < 0.0001

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