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Fig. 2 | Respiratory Research

Fig. 2

From: IL-4Rα blockade reduces influenza-associated morbidity in a murine model of allergic asthma

Fig. 2

House dust mite (HDM)-sensitization induces greater pandemic H1N1 (pH1N1)-associated weight loss and a dampened innate antiviral response. Mice were intranasally exposed to phosphate-buffered saline (PBS) or HDM for three consecutive weeks, and a single intranasal inoculation of chorioallantoic fluid (CAF) or pH1N1 was performed on day 0. a Mice were weighed daily, and mean change in body mass is plotted as a percentage of weight on day 0. Data represent two independent experiments, and were compared using two-way ANOVA with a Bonferroni correction (n = 10 per group, except n = 9 for HDM + pH1N1). b ELISA was performed on the supernatant of bronchoalveolar lavage fluid (BALF) collected on day 4 post-infection to determine the protein concentration of IFN-β. cj qPCR was performed on RNA from homogenized lung to determine the gene expression of Interferon stimulated genes (n = 5 per group). Data were compared using a Mann–Whitney U test, and are expressed as mean ± SEM. *P < 0.05; **P < 0.01; ****P < 0.0001; ns: not significant

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