TY - JOUR AU - Saito, Tsutomu AU - Ichikawa, Tomohiro AU - Numakura, Tadahisa AU - Yamada, Mitsuhiro AU - Koarai, Akira AU - Fujino, Naoya AU - Murakami, Koji AU - Yamanaka, Shun AU - Sasaki, Yusaku AU - Kyogoku, Yorihiko AU - Itakura, Koji AU - Sano, Hirohito AU - Takita, Katsuya AU - Tanaka, Rie AU - Tamada, Tsutomu AU - Ichinose, Masakazu AU - Sugiura, Hisatoshi PY - 2021 DA - 2021/02/19 TI - PGC-1α regulates airway epithelial barrier dysfunction induced by house dust mite JO - Respiratory Research SP - 63 VL - 22 IS - 1 AB - The airway epithelial barrier function is disrupted in the airways of asthmatic patients. Abnormal mitochondrial biogenesis is reportedly involved in the pathogenesis of asthma. However, the role of mitochondrial biogenesis in the airway barrier dysfunction has not been elucidated yet. This study aimed to clarify whether the peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC-1α), a central regulator of mitochondrial biogenesis, is involved in the disruption of the airway barrier function induced by aeroallergens. SN - 1465-993X UR - https://doi.org/10.1186/s12931-021-01663-6 DO - 10.1186/s12931-021-01663-6 ID - Saito2021 ER -