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Fig. 2 | Respiratory Research

Fig. 2

From: Asthma-related inflammation promotes lung metastasis of breast cancer cells through CCL11–CCR3 pathway

Fig. 2

Intratracheal injection of CCL11 recombinant (recCCL11) induces 4T1 tumor cell migration to lung tissue (n = 6/group). a Timeline of experiment. Mice were challenged with i.t of recCCL11 and i.v injected with luciferase-stably transfected 4T1 cells. b, c On day 15, biophotonic monitoring of lung metastasis in animals and quantification of bioluminescence in regions of interest (ROI) determined around lungs. d, e Representative hematoxylin–eosin–stained sections of lung tissues and tumor size quantification assessed by measuring the ratio between the area of tumor foci in lungs and total lung tissue area on 8 sections per mouse in each group. Scale bar: 2.5 mm, 100 µm. Results are expressed as mean tumor area/lung area ± SEM. **p < 0.01

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