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Table 2 Comparison of lung function and CT-measurement in CODA and KOLD cohort studies

From: A comparative study of chest CT findings regarding the effects of regional dust exposure on patients with COPD living in urban areas and rural areas near cement plants

  Model 1 Model 2
  CODA KOLD   CODA KOLD  
  LSMean ± SE LSMean ± SE P LSMean ± SE LSMean ± SE P
CAT score 23.10 ± 2.64 11.70 ± 2.20  < .001    
Pulmonary function test       
 Pre-bronchodilator FEV1 (L) 1.60 ± 0.13 1.27 ± 0.09 0.040    
 Pre-bronchodilator FVC (L) 2.59 ± 0.18 2.79 ± 0.13 0.409    
 Post-bronchodilator FEV1 (L) 1.72 ± 0.12 1.40 ± 0.09 0.048    
 Post-bronchodilator FVC (L) 2.86 ± 0.18 2.93 ± 0.12 0.769    
 Post-bronchodilator FEV1/FVC 0.59 ± 0.02 0.48 ± 0.02 0.001    
 BDR, bronchodilator response 10.20 ± 2.84 12.00 ± 2.01 0.629    
CT measurement       
 Mean wall area (%) 70.20 ± 1.26 67.70 ± 0.90 0.121 70.20 ± 1.21 66.80 ± 0.88 0.028
 Emphysema index 6.07 ± 3.06 20.0 ± 2.21  < .001 6.12 ± 2.88 17.30 ± 2.10 0.002
 Emphysema index, log-transformed/exponential 4.45 ± 1.28 16.1 ± 1.19  < .001 4.46 ± 1.27 13.60 ± 1.19  < .001
 The ratio of mean lung density (expiration/inspiration) 0.95 ± 0.01 0.94 ± 0.01 0.452 0.95 ± 0.01 0.93 ± 0.01 0.077
  1. Model1: adjusted for age, gender, education, BMI, smoking status, pack-year, CCI, and exacerbation
  2. Model2: adjusted for Model1 plus post-bronchodilator FEV1 (L)
  3. CAT COPD assessment test, FEV1 forced expiratory volume in one second, FVC forced vital capacity, LSMean least-squared mean, SE standard error, BMI body mass index, CCI Charson comorbidity index
  4. LSMeans (SE) for log-transformed lung function and CT measurements were assessed by the generalized linear mixed model
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