A comparative study of chest CT findings regarding the effects of regional dust exposure on patients with COPD living in urban areas and rural areas near cement plants

Table 2 Comparison of lung function and CT-measurement in CODA and KOLD cohort studies

	Model 1			Model 2
	CODA	KOLD		CODA	KOLD
	LSMean ± SE	LSMean ± SE	P	LSMean ± SE	LSMean ± SE	P
CAT score	23.10 ± 2.64	11.70 ± 2.20	< .001
Pulmonary function test
Pre-bronchodilator FEV1 (L)	1.60 ± 0.13	1.27 ± 0.09	0.040
Pre-bronchodilator FVC (L)	2.59 ± 0.18	2.79 ± 0.13	0.409
Post-bronchodilator FEV1 (L)	1.72 ± 0.12	1.40 ± 0.09	0.048
Post-bronchodilator FVC (L)	2.86 ± 0.18	2.93 ± 0.12	0.769
Post-bronchodilator FEV1/FVC	0.59 ± 0.02	0.48 ± 0.02	0.001
BDR, bronchodilator response	10.20 ± 2.84	12.00 ± 2.01	0.629
CT measurement
Mean wall area (%)	70.20 ± 1.26	67.70 ± 0.90	0.121	70.20 ± 1.21	66.80 ± 0.88	0.028
Emphysema index	6.07 ± 3.06	20.0 ± 2.21	< .001	6.12 ± 2.88	17.30 ± 2.10	0.002
Emphysema index, log-transformed/exponential	4.45 ± 1.28	16.1 ± 1.19	< .001	4.46 ± 1.27	13.60 ± 1.19	< .001
The ratio of mean lung density (expiration/inspiration)	0.95 ± 0.01	0.94 ± 0.01	0.452	0.95 ± 0.01	0.93 ± 0.01	0.077

Model1: adjusted for age, gender, education, BMI, smoking status, pack-year, CCI, and exacerbation
Model2: adjusted for Model1 plus post-bronchodilator FEV1 (L)
CAT COPD assessment test, FEV1 forced expiratory volume in one second, FVC forced vital capacity, LSMean least-squared mean, SE standard error, BMI body mass index, CCI Charson comorbidity index
^†LSMeans (SE) for log-transformed lung function and CT measurements were assessed by the generalized linear mixed model

ISSN: 1465-993X