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Table 5 Association between individual preexisting respiratory disease and severe disease outcomes- Mortality, Mechanical ventilation and ICU admission

From: Preexisting respiratory diseases and clinical outcomes in COVID-19: a multihospital cohort study on predominantly African American population

Characteristic

Number of events n (%)

Unadjusted

Fully adjusted*

OR (95% CI)

p-value

OR (95% CI)

p-value

Mortality

 COPD

127 (40.1)

1.47 (1.14–1.88)

0.002

1.20 (0.91–1.58)

0.2

 Asthma

30 (22.4)

0.57 (0.38–0.87)

0.008

0.98 (0.61–1.58)

0.94

 Obstructive sleep apnea

31 (49.2)

2.04 (1.23–3.37)

0.005

2.59 (1.46–4.58)

0.001

 Pulmonary embolism

13 (48.1)

1.92 (0.90–4.12)

0.09

1.86 (0.82–4.23)

0.14

 Pulmonary hypertension

4 (40)

1.37 (0.38–4.87)

0.62

1.09 (0.28–4.23)

0.9

 Sarcoidosis

1 (12.5)

0.29 (0.04–2.38)

0.28

0.39 (0.04–3.46)

0.4

 Lung cancer

4 (44.4)

1.65 (0.44–6.15)

0.45

1.24 (0.30–5.10)

0.76

ICU admission

 COPD

114 (36)

1.26 (0.98–1.63)

0.07

1.20 (0.92–1.58)

0.18

 Asthma

41 (30.6)

0.95 (0.65–1.39)

0.79

1.16 (0.77–1.74)

0.47

 Obstructive sleep apnea

32 (50.8)

2.3 (1.39–3.80)

0.001

1.95 (1.14–3.32)

0.01

 Pulmonary embolism

13 (48.1)

2.30 (0.95–4.34)

0.06

2.03 (0.93–4.44)

0.08

 Pulmonary hypertension

4 (40)

1.44 (0.41–5.13)

0.57

1.25 (0.34–4.62)

0.74

 Sarcoidosis

1 (12.5)

0.31 (0.04–2.50)

0.49

0.39 (0.05–3.21)

0.38

 Lung cancer

2 (22.2)

0.62 (0.13–2.97)

0.54

0.63 (0.12–3.28)

0.58

Mechanical ventilation

 COPD

99 (31.2)

1.35 (1.04–1.76)

0.02

1.28 (0.96–1.69)

0.09

 Asthma

33 (24.6)

0.92 (0.61–1.38)

0.68

1.08 (0.69–1.67)

0.74

 Obstructive sleep apnea

31 (49.2)

2.85 (1.72–4.73)

 < 0.001

2.20 (1.28–3.78)

0.004

 Pulmonary embolism

9 (33.3)

1.42 (0.63–3.18)

0.39

1.45(0.63–3.34)

0.39

 Pulmonary hypertension

3 (30)

1.21 (0.31–4.70)

0.72

0.96 (0.23–3.92)

0.95

 Sarcoidosis

1 (12.5)

0.40 (0.0–3.28)

0.69

0.52 (0.06–4.30)

0.54

 Lung cancer

1 (11.1)

0.35 (0.04–2.82)

0.46

0.35 (0.04–3.00)

0.34

  1. *Fully adjusted for age, sex, race, BMI and comorbidities which include hypertension, coronary artery disease, diabetes, chronic kidney disease, ESRD on dialysis, congestive heart failure, any cancer, any liver disease, hyperlipidemia and history of previous stroke
  2. OR odds ratio, CI Confidence Interval