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Table 5 Association between individual preexisting respiratory disease and severe disease outcomes- Mortality, Mechanical ventilation and ICU admission

From: Preexisting respiratory diseases and clinical outcomes in COVID-19: a multihospital cohort study on predominantly African American population

Characteristic Number of events n (%) Unadjusted Fully adjusted*
OR (95% CI) p-value OR (95% CI) p-value
Mortality
 COPD 127 (40.1) 1.47 (1.14–1.88) 0.002 1.20 (0.91–1.58) 0.2
 Asthma 30 (22.4) 0.57 (0.38–0.87) 0.008 0.98 (0.61–1.58) 0.94
 Obstructive sleep apnea 31 (49.2) 2.04 (1.23–3.37) 0.005 2.59 (1.46–4.58) 0.001
 Pulmonary embolism 13 (48.1) 1.92 (0.90–4.12) 0.09 1.86 (0.82–4.23) 0.14
 Pulmonary hypertension 4 (40) 1.37 (0.38–4.87) 0.62 1.09 (0.28–4.23) 0.9
 Sarcoidosis 1 (12.5) 0.29 (0.04–2.38) 0.28 0.39 (0.04–3.46) 0.4
 Lung cancer 4 (44.4) 1.65 (0.44–6.15) 0.45 1.24 (0.30–5.10) 0.76
ICU admission
 COPD 114 (36) 1.26 (0.98–1.63) 0.07 1.20 (0.92–1.58) 0.18
 Asthma 41 (30.6) 0.95 (0.65–1.39) 0.79 1.16 (0.77–1.74) 0.47
 Obstructive sleep apnea 32 (50.8) 2.3 (1.39–3.80) 0.001 1.95 (1.14–3.32) 0.01
 Pulmonary embolism 13 (48.1) 2.30 (0.95–4.34) 0.06 2.03 (0.93–4.44) 0.08
 Pulmonary hypertension 4 (40) 1.44 (0.41–5.13) 0.57 1.25 (0.34–4.62) 0.74
 Sarcoidosis 1 (12.5) 0.31 (0.04–2.50) 0.49 0.39 (0.05–3.21) 0.38
 Lung cancer 2 (22.2) 0.62 (0.13–2.97) 0.54 0.63 (0.12–3.28) 0.58
Mechanical ventilation
 COPD 99 (31.2) 1.35 (1.04–1.76) 0.02 1.28 (0.96–1.69) 0.09
 Asthma 33 (24.6) 0.92 (0.61–1.38) 0.68 1.08 (0.69–1.67) 0.74
 Obstructive sleep apnea 31 (49.2) 2.85 (1.72–4.73)  < 0.001 2.20 (1.28–3.78) 0.004
 Pulmonary embolism 9 (33.3) 1.42 (0.63–3.18) 0.39 1.45(0.63–3.34) 0.39
 Pulmonary hypertension 3 (30) 1.21 (0.31–4.70) 0.72 0.96 (0.23–3.92) 0.95
 Sarcoidosis 1 (12.5) 0.40 (0.0–3.28) 0.69 0.52 (0.06–4.30) 0.54
 Lung cancer 1 (11.1) 0.35 (0.04–2.82) 0.46 0.35 (0.04–3.00) 0.34
  1. *Fully adjusted for age, sex, race, BMI and comorbidities which include hypertension, coronary artery disease, diabetes, chronic kidney disease, ESRD on dialysis, congestive heart failure, any cancer, any liver disease, hyperlipidemia and history of previous stroke
  2. OR odds ratio, CI Confidence Interval
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Respiratory Research

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