Fig. 5
From: Hermansky-Pudlak syndrome-2 alters mitochondrial homeostasis in the alveolar epithelium of the lung
Mitochondrial unfolded protein response is upregulated in the lungs of HPS-2 mice. a Transcript levels for Atf5, Atf4 and Chop in lungs of WT and HPS-2 mice (n = 4, each group). b Transcript levels HSP10, mtHSP70 (n = 4, each group). c Western blot for HSP10 and mtHSP70 in lungs of WT and HPS-2 mice (n = 5, each group). Beta actin was used as a loading control. Densitometry measurements are shown together. d Western blot for LONP1, HtrA2, CLPP and SIRT3 in lungs of WT and HPS-2 mice (n = 5, each group). Densitometry measurements shown on the right. Student’s t-test. *P < 0.05 vs. control group. Densitometry analyses (bar graphs) are representative n = 5 or more mouse specimens