Fig. 7
From: The novel TRPA1 antagonist BI01305834 inhibits ovalbumin-induced bronchoconstriction in guinea pigs
Effect of TRPA1 antagonism with BI01305834 on allergen-induced airway narrowing (a), histamine release (b) or exogenous histamine-induced airway narrowing (c) in vehicle (veh, 10% cyclodextrin) or TRPA1 antagonist (0.01, 0.1, 1 or 10 µM BI01305834) pretreated lung slices of ovalbumin sensitized guinea pigs. Histamine release was calculated as % of total histamine level in both slice and supernatant. Dotted line indicates spontaneous release. Data represents mean ± SEM. *p < 0.05 compared to vehicle (One-(histamine release) or Two-way (airway narrowing) ANOVA with Dunnett’s multiple comparison test). Also, the bronchodilating effect of the TRPA1 antagonist BI01305834 on allergen- and histamine-induced preconstricted tracheal strips of ovalbumin sensitized guinea pigs (d). Data represents mean ± SEM. *p < 0.05 One-way ANOVA F-test. (n = 5 animals). Veh, vehicle