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Fig. 7 | Respiratory Research

Fig. 7

From: AITC inhibits fibroblast-myofibroblast transition via TRPA1-independent MAPK and NRF2/HO-1 pathways and reverses corticosteroids insensitivity in human lung fibroblasts

Fig. 7

Effect of AITC on glucocorticoid sensitivity after IL-4/IL-13 or TGF-β1 treatment. Relative gene expressions of α-SMA and periostin demonstrating a the sensitivity after treatment with dexamethasone (DEX) (10 μM) for 24 h in the second half during IL-4/IL-13 (20 ng/mL each) stimulation for 48 h and b the sensitivity to dexamethasone (DEX) (10 μM) for 24 h in the second half during TGF-β1 (5 ng/mL) stimulation for 48 h (*P < 0.05, * without bar; compared with the respective control). N = 3. c Western blot analysis of α-SMA protein expression where AITC (10 μM) significantly reduced TGF-β1 (5 ng/mL)-induced and DEX (10 μM)-insensitive α-SMA protein expression (*P < 0.01). N = 5

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