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Fig. 5 | Respiratory Research

Fig. 5

From: AITC inhibits fibroblast-myofibroblast transition via TRPA1-independent MAPK and NRF2/HO-1 pathways and reverses corticosteroids insensitivity in human lung fibroblasts

Fig. 5

Phosphorylation of Smad2/3 and MAPK pathways and inhibition of ERK1/2 in TGF-β1-treated fibroblasts after AITC and HC-030031 stimulation. Western blot analysis of a phosphorylated Smad 2 (p-Smad2) and Smad 3 (p-Smad3) proteins 1 h and b phosphorylated ERK1/2 MAPK (p-ERK1/2) 24hrs after treatment with AITC (10 μM) or AITC (10 μM) + HC-030031 (10 μM) during TGF-β1 stimulation. c Western blot analysis of α-SMA protein expression after treatment with U0126, ERK1/2 inhibitor (10 μM), AITC (10 μM), or AITC (10 μM) + U0126 (10 μM) during TGF-β1 stimulation. (*P < 0.05, * without bar; compared with the respective control). N = 6

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Respiratory Research

ISSN: 1465-993X

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