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Table 3 Frequency of pathological patterns parameters defined by tertiles of time from hospital admission till death (0 to 8 days; 9 to 16 days; and 17 to 40 days). Data presented as median (range)

From: Tracking the time course of pathological patterns of lung injury in severe COVID-19

  Time elapsed between hospital admission and death *P
0 to 8 days (n = 13) 9 to 16 days (n = 15) 17 to 40 days (n = 13)
Normal lung 18.33 (0–86) 15.71 (0–85) 24 (0–83.29) 0.953
Exudative DAD 31.25 (0–75.71)# 27.38 (0–92.86) 0.13 (0–58.75) 0.017
Intermediate DAD 14.29 (0–98.75) 12.5 (0–77.63) 38.57 (0–90.63) 0.355
Advanced DAD 0 (0–16.88) 0 (0–92.86) 2.5 (0–99) 0.036
Alveolar Hemorrhage 0 (0–20) 0.14 (0–32.5) 0 (0–8.75) 0.412
Infarction 0 (0–0) 0 (0–1.43) 0 (0–10.71) 0.192
Bronchopneumonia 0 (0–33.75) 0 (0–15) 0 (0–5) 0.372
Arteriolar thrombosis 0.5 (0–1.38) 1 (0–3.67) 0.71 ( 0–9.57) 0.200
Capillary thrombosis 0 (0–6) 2 (0–6) 0 ( 0 -7) 0.473
  1. *P = Comparison of a given histological parameter among tertiles of time elapsed between admission and death. Exudative DAD: #0 to 8 days ≠ 17 to 40 days (p = 0.023); Advanced DAD: 9 to 16 days ≠ 17 to 40 days (p = 0.036)
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