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Table 3 Frequency of pathological patterns parameters defined by tertiles of time from hospital admission till death (0 to 8 days; 9 to 16 days; and 17 to 40 days). Data presented as median (range)

From: Tracking the time course of pathological patterns of lung injury in severe COVID-19

 

Time elapsed between hospital admission and death

*P

0 to 8 days (n = 13)

9 to 16 days (n = 15)

17 to 40 days (n = 13)

Normal lung

18.33 (0–86)

15.71 (0–85)

24 (0–83.29)

0.953

Exudative DAD

31.25 (0–75.71)#

27.38 (0–92.86)

0.13 (0–58.75)

0.017

Intermediate DAD

14.29 (0–98.75)

12.5 (0–77.63)

38.57 (0–90.63)

0.355

Advanced DAD

0 (0–16.88)

0 (0–92.86)

2.5 (0–99)

0.036

Alveolar Hemorrhage

0 (0–20)

0.14 (0–32.5)

0 (0–8.75)

0.412

Infarction

0 (0–0)

0 (0–1.43)

0 (0–10.71)

0.192

Bronchopneumonia

0 (0–33.75)

0 (0–15)

0 (0–5)

0.372

Arteriolar thrombosis

0.5 (0–1.38)

1 (0–3.67)

0.71 ( 0–9.57)

0.200

Capillary thrombosis

0 (0–6)

2 (0–6)

0 ( 0 -7)

0.473

  1. *P = Comparison of a given histological parameter among tertiles of time elapsed between admission and death. Exudative DAD: #0 to 8 days ≠ 17 to 40 days (p = 0.023); Advanced DAD: 9 to 16 days ≠ 17 to 40 days (p = 0.036)