From: Tracking the time course of pathological patterns of lung injury in severe COVID-19
Female/male | 18/23 |
Caucasians, n (%) | 35 (85%) |
Age in years, median (range) | 55 (22—88) |
Body mass index, median (range) | 26 (13—48) |
Comorbidities, n (%) | |
Diabetes | 13 (32.5%) |
Systemic arterial hypertension | 20 (50%) |
Cardiomyopathy | 10 (25%) |
Vascular disase | 5 (12.5%) |
Chronic kidney disease | 4 (10%) |
Asthma | 2 (5%) |
Chronic obstructive pulmonary disease | 5 (12.5%) |
Smoker | 4 (10%) |
Comorbidities number | |
1 | 20 (54.1%) |
2 | 10 (27%) |
3 | 2 (5.4%) |
4 | 3 (8.1%) |
5 | 2 (5.4%) |
Symptoms, n (%) | |
Fever | 29 (72.5%) |
Dyspnoea | 33 (82.5%) |
Cough | 27 (67.5%) |
Rhinorrhea | 6 (15%) |
Diarrhoea | 9 (22.5%) |
Myalgia | 14 (35%) |
Sore throat | 5 (12.5%) |
Nausea and vomiting | 10 (25%) |
Others | 15 (37.5%) |
Use of corticosteroids, n (%) | 23 (57.5%) |
Use of anticoagulants, n (%) | 11 (30.8%) |
Use of vasoactive drugs (admission), n = 37 | 15 (40.5%) |
Use of mechanical ventilation, n = 37 | 37 (100%) |
Prone positioning, n = 37 | 12 (32.4%) |
Extracorporeal membrane oxygenation, n = 37 | 4 (10.8%) |
Dialysis, n = 37 | 20 (54.1%) |
Glasgow coma scale (day 1), n = 37 | 3 (3–15) |
Simplified acute physiology score III (day 1), n = 37 | 66 (39–97) |
Laboratory parameters from 24 h before death, median (range) | |
D Dimer (ng/ml), n = 32 | 4593 (815–126,078) |
Fibrinogen (mg/dl), n = 20 | 485.5 (89–2465) |
Platelets (ml/mm3), n = 39 | 158,000 (4000–322,000) |
Activated partial thromboplastin time (s), n = 32 | 1.23 (0.92–7.0) |
Lymphocytes (ml/mm3), n = 39 | 0.37 (0.04–1.05) |
Lung parameters from 24 h before death, median (range) | |
PEEP (cmH2O), n = 35 | 10 (5–20) |
FiO2 (%), n = 35 | 60 (25–100) |
PaO2/FiO2 ratio, n = 28 | 122.5 (56–430) |
Time from symptom onset to hospitalization in days, median (range) | 5 (0–26) |
Time from symptom onset to death in days, median (range) | 18 (3–47) |
Period of hospitalisation in days, median (range) | 12 (0–40) |
Intensive care unit stay in days, median (range) | 9 (0–38) |
Period of mechanical ventilation in days, median (range) | 11 (0–39) |