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Fig. 1 | Respiratory Research

Fig. 1

From: Tracking the time course of pathological patterns of lung injury in severe COVID-19

Fig. 1

Histopathological parameters. a Diffuse Alveolar Damage, exudative. Observe the septa with mixed inflammatory infiltrate, hyaline membranes, desquamated pneumocytes and macrophages in the alveolar lumen. b Diffuse Alveolar Damage, advanced. Pulmonary architecture is altered, with fibrotic bundles substituting the alveolar parenchyma and distortion of the wall of an airway. c and d Diffuse Alveolar Damage, intermediate. Alveolar spaces are diffusely filled with oedematous, myxoid connective tissue, indicating areas of early fibroproliferation. In d, one can observe the presence of hyaline membranes. e Alveolar haemorrhage. The alveolar spaces are filled with red blood cells and oedematous fluid. f Bronchopneumonia. Alveolar cells are filled with neutrophils and macrophages. There are no hyaline membranes. g Fibrinous, in organization thrombus in a pulmonary artery branch. h Multiple fibrin clots in alveolar capillaries (arrow). In the link https://pathpresenter.net/#/public/display?token=5a84d5d9 one has access to the scanned images of the examples above

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