Fig. 4

Schematic depiction of TBX4-FGF10 and SHH-FOXF1 signaling regulating branching morphogenesis. Dark grey denotes epithelium and light grey represents mesenchyme. Suggested regulation of FOXF1 by TBX4 and TBX2 (solid lines) is based on TF binding pattern detected in ChIP-seq experiment presented in this work. Interactions between epithelial SHH and mesenchymal FOXF1 and FGF10 (dotted lines) as well as T-Box TF and FGF10 (dashed lines) are proposed based on the literature data [5, 16, 47]. Arrowheads indicate direction of protein–protein interactions