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Table 4 Longitudinal association between decreased telomere length and lung function and clinical variables during 10 year-follow-up

From: Telomere length dynamics over 10-years and related outcomes in patients with COPD

 

Total patients (n = 134)

Deaths during follow-up (n = 43)

Alive patients (n = 91)

 

β

p-value

β

p-value

β

p-value

FEV1 (L)

0.13

0.022

0.17

0.112

0.11

0.104

FEV1 (% pred)

0.56

0.784

2.91

0.501

0.59

0.798

FEV1/FVC (% pred)

0.445

0.0008

0.579

0.024

0.377

0.015

PaO2

0.771

< 0.0001

1.398

0.0003

0.443

0.053

IC/TLC (%)

0.006

< 0.0001

0.006

0.021

0.006

0.0009

KCO

0.877

0.042

1.325

0.092

0.817

0.106

6MWD (mts)

4.655

0.004

10.53

0.007

1.769

0.299

BODE index

− 0.081

0.009

− 0.219

0.002

− 0.013

0.689

  1. Linear regression of mixed models. β, coefficient
  2. FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, % pred per cent predicted, PaO2 partial oxygen tension, KCO transfer factor coefficient of the lung for carbon monoxide, which is DLCO, IC/TLC inspiratory capacity to total lung capacity ratio, 6MWD 6 min walking distance test. p-values < 0.05 are shown in italics