Withdrawal of inhaled corticosteroids versus continuation of triple therapy in patients with COPD in real life: observational comparative effectiveness study

Table 6 Determinants of successful ICS cessation

Variable	Total	Event	Univariate analysis			Multivariate analysis
Variable	Total	Event	HR	95% CI	p-value	HR	95% CI	p-value
Asthma diagnosis pre-baseline
No	899	223 (24.8%)		Ref
Yes	147	24 (16.3%)	0.59	0.37 to 0.94	0.026
Blood eosinophil count
< 0.1	99	27 (27.2%)		Ref
≥ 0.1 to < 0.3	608	145 (23.8%)	0.84	0.52 to 1.35	0.462	0.76	0.47 to 1.27	0.282
≥ 0.3	182	31 (17.0%)	0.55	0.30 to 0.99	0.044	0.50	0.27 to 0.91	0.023
Exacerbations managed in primary care in baseline year
0	535	171 (31.9%)		Ref
1	258	55 (21.3%)	0.58	0.41 to 0.82	0.002
2	119	12 (10.1%)	0.24	0.13 to 0.45	< 0.001
3+	134	9 (6.7%)	0.15	0.08 to 0.31	< 0.001
Antibiotic prescriptions in baseline year
0	553	175 (31.6%)		Ref
1	243	51 (20.9%)	0.57	0.40 to 0.82	0.002
2	107	9 (8.4%)	0.20	0.10 to 0.40	< 0.001
3+	143	12 (8.4%)	0.20	0.11 to 0.37	< 0.001
OCS prescriptions in baseline year
0	476	155 (32.5%)		Ref
1	183	46 (25.1%)	0.70	0.47 to 1.02	0.064	0.70	0.45 to 1.05	0.090
2	116	13 (11.2%)	0.26	0.14 to 0.48	< 0.001	0.23	0.11 to 0.44	< 0.001
3+	271	33 (12.2%)	0.29	0.19 to 0.43	< 0.001	0.31	0.19 to 0.47	< 0.001

ISSN: 1465-993X