|
Variable
|
Total
|
Event
| |
Univariate analysis
|
Multivariate analysis
|
|---|
| |
HR
|
95% CI
|
p-value
| |
HR
|
95% CI
|
p-value
|
|---|
|
Asthma diagnosis pre-baseline
| | | | | | | | |
|
No
|
899
|
223 (24.8%)
| | |
Ref
| | | | | |
|
Yes
|
147
|
24 (16.3%)
| |
0.59
|
0.37 to 0.94
|
0.026
| | | | |
|
Blood eosinophil count
| | | | | | | | |
|
< 0.1
|
99
|
27 (27.2%)
| | |
Ref
| | | | | |
|
≥ 0.1 to < 0.3
|
608
|
145 (23.8%)
| |
0.84
|
0.52 to 1.35
|
0.462
| |
0.76
|
0.47 to 1.27
|
0.282
|
|
≥ 0.3
|
182
|
31 (17.0%)
| |
0.55
|
0.30 to 0.99
|
0.044
| |
0.50
|
0.27 to 0.91
|
0.023
|
|
Exacerbations managed in primary care in baseline year
| | | | | |
|
0
|
535
|
171 (31.9%)
| | |
Ref
| | | | | |
|
1
|
258
|
55 (21.3%)
| |
0.58
|
0.41 to 0.82
|
0.002
| | | | |
|
2
|
119
|
12 (10.1%)
| |
0.24
|
0.13 to 0.45
|
< 0.001
| | | | |
|
3+
|
134
|
9 (6.7%)
| |
0.15
|
0.08 to 0.31
|
< 0.001
| | | | |
|
Antibiotic prescriptions in baseline year
| |
|
0
|
553
|
175 (31.6%)
| | |
Ref
| | | | |
|
1
|
243
|
51 (20.9%)
| |
0.57
|
0.40 to 0.82
|
0.002
| | | |
|
2
|
107
|
9 (8.4%)
| |
0.20
|
0.10 to 0.40
|
< 0.001
| | | |
|
3+
|
143
|
12 (8.4%)
| |
0.20
|
0.11 to 0.37
|
< 0.001
| | | |
|
OCS prescriptions in baseline year
| |
|
0
|
476
|
155 (32.5%)
| | |
Ref
| | | | |
|
1
|
183
|
46 (25.1%)
| |
0.70
|
0.47 to 1.02
|
0.064
|
0.70
|
0.45 to 1.05
|
0.090
|
|
2
|
116
|
13 (11.2%)
| |
0.26
|
0.14 to 0.48
|
< 0.001
|
0.23
|
0.11 to 0.44
|
< 0.001
|
|
3+
|
271
|
33 (12.2%)
| |
0.29
|
0.19 to 0.43
|
< 0.001
|
0.31
|
0.19 to 0.47
|
< 0.001
|
