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Table 6 Determinants of successful ICS cessation

From: Withdrawal of inhaled corticosteroids versus continuation of triple therapy in patients with COPD in real life: observational comparative effectiveness study

Variable Total Event   Univariate analysis Multivariate analysis
  HR 95% CI p-value   HR 95% CI p-value
Asthma diagnosis pre-baseline         
 No 899 223 (24.8%)    Ref      
 Yes 147 24 (16.3%)   0.59 0.37 to 0.94 0.026     
Blood eosinophil count         
 < 0.1 99 27 (27.2%)    Ref      
 ≥ 0.1 to < 0.3 608 145 (23.8%)   0.84 0.52 to 1.35 0.462   0.76 0.47 to 1.27 0.282
 ≥ 0.3 182 31 (17.0%)   0.55 0.30 to 0.99 0.044   0.50 0.27 to 0.91 0.023
Exacerbations managed in primary care in baseline year      
 0 535 171 (31.9%)    Ref      
 1 258 55 (21.3%)   0.58 0.41 to 0.82 0.002     
 2 119 12 (10.1%)   0.24 0.13 to 0.45 < 0.001     
 3+ 134 9 (6.7%)   0.15 0.08 to 0.31 < 0.001     
Antibiotic prescriptions in baseline year  
 0 553 175 (31.6%)    Ref     
 1 243 51 (20.9%)   0.57 0.40 to 0.82 0.002    
 2 107 9 (8.4%)   0.20 0.10 to 0.40 < 0.001    
 3+ 143 12 (8.4%)   0.20 0.11 to 0.37 < 0.001    
OCS prescriptions in baseline year  
 0 476 155 (32.5%)    Ref     
 1 183 46 (25.1%)   0.70 0.47 to 1.02 0.064 0.70 0.45 to 1.05 0.090
 2 116 13 (11.2%)   0.26 0.14 to 0.48 < 0.001 0.23 0.11 to 0.44 < 0.001
 3+ 271 33 (12.2%)   0.29 0.19 to 0.43 < 0.001 0.31 0.19 to 0.47 < 0.001