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Table 1 Patient demographics and clinical characteristics

From: Withdrawal of inhaled corticosteroids versus continuation of triple therapy in patients with COPD in real life: observational comparative effectiveness study

  Total
No. 5230
Control
No. 4184
ICS cessation
No. 1046
p-value
Age, years     
 Mean (SD) 70.8 (± 9.9) 70.7 (± 10.2) 71.0 (± 8.8) 0.61
Sex     
 Female 2330 (44.6%) 1872 (44.7%) 458 (43.8%) 0.60
 Male 2900 (55.4%) 2312 (55.3%) 588 (56.2%)  
BMI category     
 Mean (SD) 27.3 (± 7.6) 27.1 (± 7.3) 28.1 (± 8.7) < 0.001
 Missing 204 (3.9%) 181 (4.3%) 23 (2.2%)  
Smoking status     
 Current smoker 1813 (34.7%) 1467 (35.1%) 346 (33.1%) 0.24
 Ex-smoker 3417 (65.3%) 2717 (64.9%) 700 (66.9%)  
FEV1% predicted     
 Mean (SD) 54.8 (± 22.2) 53.9 (± 22.5) 58.2 (± 20.9) 0.003
 Missing 471 (9.0%) 417 (10.0%) 54 (5.2%)  
Blood eosinophil count     
 < 0.1 370 (8.6%) 271 (8.0%) 99 (11.1%) 0.006
 ≥ 0.1 to < 0.3 2947 (68.7%) 2339 (68.8%) 608 (68.4%)  
 ≥ 0.3 970 (22.6%) 788 (23.2%) 182 (20.5%)  
 Missing 943 (18.0%) 786 (18.8%) 157 (15.0%)  
CAT score     
 Mean (SD) 16.8 (± 9.3) 17.1 (± 9.6) 16.0 (± 8.5) 0.057
 Missing 4056 (77.6%) 3370 (80.5%) 686 (65.6%)  
mMRC dyspnea scale     
 Mean (SD) 1.9 (± 1.0) 1.9 (± 1.0) 1.8 (± 0.9) < 0.001
 Missing 340 (6.5%) 300 (7.2%) 40 (3.8%)  
Time since first COPD diagnosis, year     
 Mean (SD) 8.5 (± 6.7) 8.5 (± 6.8) 8.5 (± 6.2) 0.37
 Missing 152 (2.9%) 124 (3.0%) 28 (2.7%)  
Comorbidities     
 Asthma (diagnosed pre baseline)a 1273 (24.3%) 1126 (26.9%) 147 (14.1%) < 0.001
 Asthma (diagnosed in year post IPD) 18 (0.34%) 12 (0.29%) 6 (0.57%) 0.23
 Bronchiectasis 368 (7.0%) 304 (7.3%) 64 (6.1%) 0.22
 Active rhinitis 1146 (21.9%) 918 (21.9%) 228 (21.8%) 0.93
 Nasal polyps 128 (2.4%) 105 (2.5%) 23 (2.2%) 0.65
 Active GERD 2517 (48.1%) 1971 (47.1%) 546 (52.2%) 0.003
 Cardiovascular disease 2358 (45.1%) 1892 (45.2%) 466 (44.6%) 0.70
 Ischaemic heart disease 1161 (22.2%) 935 (22.3%) 226 (21.6%) 0.62
 Heart failure 537 (10.3%) 444 (10.6%) 93 (8.9%) 0.11
 Myocardial infarction 591 (11.3%) 472 (11.3%) 119 (11.4%) 0.91
 Cerebrovascular disease 424 (8.1%) 347 (8.3%) 77 (7.4%) 0.34
 Hypertension 2483 (47.5%) 1961 (46.9%) 522 (49.9%) 0.083
 Diabetes 1040 (19.9%) 837 (20.0%) 203 (19.4%) 0.70
 Osteoporosis 682 (13.0%) 553 (13.2%) 129 (12.3%) 0.47
 Anxiety and/or depression 2341 (44.8%) 1871 (44.7%) 470 (44.9%) 0.92
 Chronic kidney disease 861 (16.5%) 695 (16.6%) 166 (15.9%) 0.58
 Other chronic diseases 920 (17.6%) 768 (18.4%) 152 (14.5%) 0.004
  1. aResolved or Read code prior to, but not during, baseline year