| Total No. 5230 | Control No. 4184 | ICS cessation No. 1046 | p-value |
---|---|---|---|---|
Age, years | Â | Â | Â | Â |
 Mean (SD) | 70.8 (± 9.9) | 70.7 (± 10.2) | 71.0 (± 8.8) | 0.61 |
Sex | Â | Â | Â | Â |
 Female | 2330 (44.6%) | 1872 (44.7%) | 458 (43.8%) | 0.60 |
 Male | 2900 (55.4%) | 2312 (55.3%) | 588 (56.2%) |  |
BMI category | Â | Â | Â | Â |
 Mean (SD) | 27.3 (± 7.6) | 27.1 (± 7.3) | 28.1 (± 8.7) | < 0.001 |
 Missing | 204 (3.9%) | 181 (4.3%) | 23 (2.2%) |  |
Smoking status | Â | Â | Â | Â |
 Current smoker | 1813 (34.7%) | 1467 (35.1%) | 346 (33.1%) | 0.24 |
 Ex-smoker | 3417 (65.3%) | 2717 (64.9%) | 700 (66.9%) |  |
FEV1% predicted | Â | Â | Â | Â |
 Mean (SD) | 54.8 (± 22.2) | 53.9 (± 22.5) | 58.2 (± 20.9) | 0.003 |
 Missing | 471 (9.0%) | 417 (10.0%) | 54 (5.2%) |  |
Blood eosinophil count | Â | Â | Â | Â |
 < 0.1 | 370 (8.6%) | 271 (8.0%) | 99 (11.1%) | 0.006 |
 ≥ 0.1 to < 0.3 | 2947 (68.7%) | 2339 (68.8%) | 608 (68.4%) |  |
 ≥ 0.3 | 970 (22.6%) | 788 (23.2%) | 182 (20.5%) |  |
 Missing | 943 (18.0%) | 786 (18.8%) | 157 (15.0%) |  |
CAT score | Â | Â | Â | Â |
 Mean (SD) | 16.8 (± 9.3) | 17.1 (± 9.6) | 16.0 (± 8.5) | 0.057 |
 Missing | 4056 (77.6%) | 3370 (80.5%) | 686 (65.6%) |  |
mMRC dyspnea scale | Â | Â | Â | Â |
 Mean (SD) | 1.9 (± 1.0) | 1.9 (± 1.0) | 1.8 (± 0.9) | < 0.001 |
 Missing | 340 (6.5%) | 300 (7.2%) | 40 (3.8%) |  |
Time since first COPD diagnosis, year | Â | Â | Â | Â |
 Mean (SD) | 8.5 (± 6.7) | 8.5 (± 6.8) | 8.5 (± 6.2) | 0.37 |
 Missing | 152 (2.9%) | 124 (3.0%) | 28 (2.7%) |  |
Comorbidities | Â | Â | Â | Â |
 Asthma (diagnosed pre baseline)a | 1273 (24.3%) | 1126 (26.9%) | 147 (14.1%) | < 0.001 |
 Asthma (diagnosed in year post IPD) | 18 (0.34%) | 12 (0.29%) | 6 (0.57%) | 0.23 |
 Bronchiectasis | 368 (7.0%) | 304 (7.3%) | 64 (6.1%) | 0.22 |
 Active rhinitis | 1146 (21.9%) | 918 (21.9%) | 228 (21.8%) | 0.93 |
 Nasal polyps | 128 (2.4%) | 105 (2.5%) | 23 (2.2%) | 0.65 |
 Active GERD | 2517 (48.1%) | 1971 (47.1%) | 546 (52.2%) | 0.003 |
 Cardiovascular disease | 2358 (45.1%) | 1892 (45.2%) | 466 (44.6%) | 0.70 |
 Ischaemic heart disease | 1161 (22.2%) | 935 (22.3%) | 226 (21.6%) | 0.62 |
 Heart failure | 537 (10.3%) | 444 (10.6%) | 93 (8.9%) | 0.11 |
 Myocardial infarction | 591 (11.3%) | 472 (11.3%) | 119 (11.4%) | 0.91 |
 Cerebrovascular disease | 424 (8.1%) | 347 (8.3%) | 77 (7.4%) | 0.34 |
 Hypertension | 2483 (47.5%) | 1961 (46.9%) | 522 (49.9%) | 0.083 |
 Diabetes | 1040 (19.9%) | 837 (20.0%) | 203 (19.4%) | 0.70 |
 Osteoporosis | 682 (13.0%) | 553 (13.2%) | 129 (12.3%) | 0.47 |
 Anxiety and/or depression | 2341 (44.8%) | 1871 (44.7%) | 470 (44.9%) | 0.92 |
 Chronic kidney disease | 861 (16.5%) | 695 (16.6%) | 166 (15.9%) | 0.58 |
 Other chronic diseases | 920 (17.6%) | 768 (18.4%) | 152 (14.5%) | 0.004 |