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Table 1 Patient demographics and clinical characteristics

From: Withdrawal of inhaled corticosteroids versus continuation of triple therapy in patients with COPD in real life: observational comparative effectiveness study

 

Total

No. 5230

Control

No. 4184

ICS cessation

No. 1046

p-value

Age, years

    

 Mean (SD)

70.8 (± 9.9)

70.7 (± 10.2)

71.0 (± 8.8)

0.61

Sex

    

 Female

2330 (44.6%)

1872 (44.7%)

458 (43.8%)

0.60

 Male

2900 (55.4%)

2312 (55.3%)

588 (56.2%)

 

BMI category

    

 Mean (SD)

27.3 (± 7.6)

27.1 (± 7.3)

28.1 (± 8.7)

< 0.001

 Missing

204 (3.9%)

181 (4.3%)

23 (2.2%)

 

Smoking status

    

 Current smoker

1813 (34.7%)

1467 (35.1%)

346 (33.1%)

0.24

 Ex-smoker

3417 (65.3%)

2717 (64.9%)

700 (66.9%)

 

FEV1% predicted

    

 Mean (SD)

54.8 (± 22.2)

53.9 (± 22.5)

58.2 (± 20.9)

0.003

 Missing

471 (9.0%)

417 (10.0%)

54 (5.2%)

 

Blood eosinophil count

    

 < 0.1

370 (8.6%)

271 (8.0%)

99 (11.1%)

0.006

 ≥ 0.1 to < 0.3

2947 (68.7%)

2339 (68.8%)

608 (68.4%)

 

 ≥ 0.3

970 (22.6%)

788 (23.2%)

182 (20.5%)

 

 Missing

943 (18.0%)

786 (18.8%)

157 (15.0%)

 

CAT score

    

 Mean (SD)

16.8 (± 9.3)

17.1 (± 9.6)

16.0 (± 8.5)

0.057

 Missing

4056 (77.6%)

3370 (80.5%)

686 (65.6%)

 

mMRC dyspnea scale

    

 Mean (SD)

1.9 (± 1.0)

1.9 (± 1.0)

1.8 (± 0.9)

< 0.001

 Missing

340 (6.5%)

300 (7.2%)

40 (3.8%)

 

Time since first COPD diagnosis, year

    

 Mean (SD)

8.5 (± 6.7)

8.5 (± 6.8)

8.5 (± 6.2)

0.37

 Missing

152 (2.9%)

124 (3.0%)

28 (2.7%)

 

Comorbidities

    

 Asthma (diagnosed pre baseline)a

1273 (24.3%)

1126 (26.9%)

147 (14.1%)

< 0.001

 Asthma (diagnosed in year post IPD)

18 (0.34%)

12 (0.29%)

6 (0.57%)

0.23

 Bronchiectasis

368 (7.0%)

304 (7.3%)

64 (6.1%)

0.22

 Active rhinitis

1146 (21.9%)

918 (21.9%)

228 (21.8%)

0.93

 Nasal polyps

128 (2.4%)

105 (2.5%)

23 (2.2%)

0.65

 Active GERD

2517 (48.1%)

1971 (47.1%)

546 (52.2%)

0.003

 Cardiovascular disease

2358 (45.1%)

1892 (45.2%)

466 (44.6%)

0.70

 Ischaemic heart disease

1161 (22.2%)

935 (22.3%)

226 (21.6%)

0.62

 Heart failure

537 (10.3%)

444 (10.6%)

93 (8.9%)

0.11

 Myocardial infarction

591 (11.3%)

472 (11.3%)

119 (11.4%)

0.91

 Cerebrovascular disease

424 (8.1%)

347 (8.3%)

77 (7.4%)

0.34

 Hypertension

2483 (47.5%)

1961 (46.9%)

522 (49.9%)

0.083

 Diabetes

1040 (19.9%)

837 (20.0%)

203 (19.4%)

0.70

 Osteoporosis

682 (13.0%)

553 (13.2%)

129 (12.3%)

0.47

 Anxiety and/or depression

2341 (44.8%)

1871 (44.7%)

470 (44.9%)

0.92

 Chronic kidney disease

861 (16.5%)

695 (16.6%)

166 (15.9%)

0.58

 Other chronic diseases

920 (17.6%)

768 (18.4%)

152 (14.5%)

0.004

  1. aResolved or Read code prior to, but not during, baseline year