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Fig. 2 | Respiratory Research

Fig. 2

From: Glycopyrrolate/formoterol fumarate metered dose inhaler for maintenance-naïve patients with chronic obstructive pulmonary disease: a post-hoc analysis of the randomized PINNACLE trials

Fig. 2

Time to first CID event for NMT (a) and MT (b) patients. Time to CID (weeks) = (date of CID – first treatment administration date + 1)/7. CID was defined as the first occurrence of one of the following events: ≥100 mL decline in trough FEV1, treatment-emergent moderate or severe COPD exacerbation, or increase of ≥ 4.0 units in SGRQ score. CID = clinically important deterioration; COPD = chronic obstructive pulmonary disease; FEV1 = forced expiratory volume in 1 s; FF = formoterol fumarate; GFF = glycopyrrolate/formoterol fumarate; GP = glycopyrrolate; MDI = metered dose inhaler; MT = maintenance-treated at screening; NMT = not maintenance-treated at screening; SGRQ = St George’s Respiratory Questionnaire

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