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Fig. 1 | Respiratory Research

Fig. 1

From: Glycopyrrolate/formoterol fumarate metered dose inhaler for maintenance-naïve patients with chronic obstructive pulmonary disease: a post-hoc analysis of the randomized PINNACLE trials

Fig. 1

Pre-dose trough and peak post-dose FEV1 for NMT (a, c) and MT (b, d) patients. P < 0.0001 for all comparisons excluding FF versus GP. All P-values < 0.05 should only be interpreted in terms of nominal significance as the analyses in these subgroups were exploratory and post-hoc. Interrupted line at 100 mL indicates MCID for change in trough FEV1 (1A and 1B). COPD = chronic obstructive pulmonary disease; FEV1 = forced expiratory volume over 1 s; FF = formoterol fumarate; GFF = glycopyrrolate/formoterol fumarate; GP = glycopyrrolate; LSM = least squares mean; MCID = minimal clinically important difference; MT = maintenance-treated at screening; NMT = not maintenance-treated at screening; SE = standard error

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